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首页> 外文期刊>Peritoneal dialysis international: Journal of the International Society for Peritoneal Dialysis >Initiating CAPD with a regimen low in glucose and glucose degradation products, with icodextrin and amino acids (NEPP) is safe and efficacious.
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Initiating CAPD with a regimen low in glucose and glucose degradation products, with icodextrin and amino acids (NEPP) is safe and efficacious.

机译：以低糖和葡萄糖降解产物，艾考糊精和氨基酸（NEPP）的方案启动CAPD是安全有效的。

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BACKGROUND: The high Levels of glucose, glucose degradation products (GDPs), and lactate buffer present in standard peritoneal dialysis (PD) solutions contribute to peritoneal damage, malnutrition, and dyslipidemia. Therefore, we studied the feasibility of a PD regimen as low as possible in glucose and GDPs. METHODS: In a prospective 30-week study, patients new to continuous ambulatory PD (CAPD) were randomized to either a standard PD regimen (SPD; 4 dwells glucose-/lactate-based) or a low glucose-GDP regimen (NEPP; 1 dwell amino acids, 1 dwell icodextrin, and two dwells bicarbonate/lactate-buffered glucose-based solution). RESULTS: Results obtained during a 30-week study period for 63 new CAPD patients (30 NEPP, 33 SPD) were analyzed. Intraperitoneal glucose load was lower in the NEPP group (111 +/- 76 vs 159 +/- 40 g/day at 30 weeks, p < 0.001). Dialysis efficacy, ultrafiltration, weight, blood pressure, and laboratory results were similar in the groups, whereas, in the NEPP group, cancer antigen 125in dialysate effluents decreased less but dialysate-to-plasma ratios were slightly higher. CONCLUSION: Short-term treatment of new CAPD patients with a PD regimen low in glucose and GDPs is feasible. Dialysis efficacy, ultrafiltration, and metabolic consequences are similar to those during a standard glucose-lactate-based regimen, whereas peritoneal transport seems slightly higher and preservation of mesothelial cell mass better during NEPP.
机译：背景：标准腹膜透析（PD）解决方案中存在的高水平葡萄糖，葡萄糖降解产物（GDPs）和乳酸缓冲液有助于腹膜损害，营养不良和血脂异常。因此，我们研究了尽可能降低血糖和GDP的PD方案的可行性。方法：在一项为期30周的前瞻性研究中，将连续动态门诊PD（CAPD）的新患者随机分为标准PD方案（SPD; 4例基于葡萄糖/乳酸盐的住院）或低血糖GDP方案（NEPP; 1）。驻留氨基酸，1个驻留艾考糊精和2个驻留碳酸氢盐/乳酸盐缓冲的葡萄糖基溶液）。结果：分析了在30周研究期内63名新的CAPD患者（30 NEPP，33 SPD）获得的结果。 NEPP组的腹膜内葡萄糖负荷较低（30周时为111 +/- 76对159 +/- 40 g /天，p <0.001）。各组的透析功效，超滤，体重，血压和实验室检查结果相似，而在NEPP组中，透析液流出物中的癌症抗原125下降较少，但透析液与血浆的比率略高。结论：采用低血糖和低GDP的PD方案短期治疗新的CAPD患者是可行的。透析功效，超滤作用和代谢后果与标准的基于葡萄糖-乳酸的方案相似，而腹膜转运似乎略高，NEPP期间的间皮细胞保存更好。

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