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首页> 外文期刊>Peritoneal dialysis international: Journal of the International Society for Peritoneal Dialysis >The effects of irbesartan and spironolactone in prevention of peritoneal fibrosis in rats.
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The effects of irbesartan and spironolactone in prevention of peritoneal fibrosis in rats.

机译：厄贝沙坦和螺内酯对大鼠腹膜纤维化的预防作用。

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BACKGROUND: Bacterial peritonitis episodes may disturb the functional and histological integrity of the peritoneum in peritoneal dialysis patients. The renin-angiotensin-aldosterone system may have fibrotic effects on the peritoneum. OBJECTIVE: To study the effects of an angiotensin II receptor antagonist (irbesartan) and an aldosterone antagonist (spironolactone) in the prevention of peritoneal fibrosis in a rat model of bacterial peritonitis. METHODS: 40 Wistar rats were randomized into 5 groups: bacteria (B), bacteria-irbesartan (BI), bacteria-spironolactone (BS), bacteria-irbesartan-spironolactone (BIS), and control (C) groups. The C group received only dextran beads (Cytodex; Sigma Chemicals, St Louis, Missouri, USA); the others were given bacteria and dextran beads intraperitoneally. Irbesartan and/or spironolactone were given to 3 groups: BI, BS, and BIS. On the eighth day, the rats were sacrificed, peritoneal adhesion was quantified, and peritoneal tissue sections were evaluated histologically.RESULTS: The peritoneal total adhesion score was significantly higher in the B group than in the BI, BIS, and C groups (p < 0.01). Mean peritoneal thickness, mean inflammation score, and mean fibrosis score were significantly higher in the B group in comparison to the C group (p < 0.05). Mean peritoneal thickness of all treatment groups was significantly lower than the B group (p < 0.05). Serum transforming growth factor beta-1 level was significantly higher in the B group than in the BI, BS, and C groups (p < 0.05). CONCLUSION: Irbesartan and spironolactone seem to decrease the extent of peritoneal injury caused by bacterial peritonitis.
机译：背景：细菌性腹膜炎发作可能会干扰腹膜透析患者腹膜的功能和组织学完整性。肾素-血管紧张素-醛固酮系统可能对腹膜有纤维化作用。目的：研究血管紧张素Ⅱ受体拮抗剂（厄贝沙坦）和醛固酮拮抗剂（螺内酯）在细菌性腹膜炎大鼠模型中预防腹膜纤维化的作用。方法：将40只Wistar大鼠随机分为5组：细菌（B），细菌-厄贝沙坦（BI），细菌-螺内酯（BS），细菌-厄贝沙坦-螺内酯（BIS）和对照组（C）。 C组仅接受右旋糖酐珠（Cytodex; Sigma Chemicals，美国密苏里州圣路易斯）;其余的则腹膜内给予细菌和葡聚糖珠。将厄贝沙坦和/或螺内酯分为3组：BI，BS和BIS。第八天处死大鼠，定量腹膜粘连，组织学评价腹膜组织切片。结果：B组腹膜总粘连评分明显高于BI，BIS和C组（p < 0.01）。与C组相比，B组的平均腹膜厚度，平均炎症评分和平均纤维化评分显着更高（p <0.05）。所有治疗组的平均腹膜厚度均显着低于B组（p <0.05）。 B组的血清转化生长因子β-1水平显着高于BI，BS和C组（p <0.05）。结论：厄贝沙坦和螺内酯似乎可以减少细菌性腹膜炎引起的腹膜损伤程度。

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