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首页> 外文期刊>Peritoneal dialysis international: Journal of the International Society for Peritoneal Dialysis >Combination of crystalloid (glucose) and colloid (icodextrin) osmotic agents markedly enhances peritoneal fluid and solute transport during the long PD dwell.
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Combination of crystalloid (glucose) and colloid (icodextrin) osmotic agents markedly enhances peritoneal fluid and solute transport during the long PD dwell.

机译：在长时间的PD停留期间，晶体（葡萄糖）和胶体（艾考糊精）渗透剂的组合显着增强了腹膜液和溶质的转运。

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BACKGROUND: Fluid and sodium removal is often inadequate in peritoneal dialysis patients with high peritoneal solute transport rate, especially when residual renal function is declining. METHOD: We studied the effects of using simultaneous crystalloid (glucose) and colloid (icodextrin) osmotic agents on the peritoneal transport of fluid, sodium, and other solutes during 15-hour single-dwell exchanges using 3.86% glucose, 7.5% icodextrin, and a combination fluid with 2.61% glucose and 6.8% icodextrin in 7 prevalent peritoneal dialysis patients with fast peritoneal solute transport rate. RESULTS: The combination fluid enhanced net ultrafiltration (mean 990 mL) and sodium removal (mean 158 mmol) compared with 7.5% icodextrin (mean net ultrafiltration 462 mL, mean net sodium removal 49 mmol). In contrast, the 3.86% glucose-based solution yielded negligible ultrafiltration (mean -85 mL) and sodium removal (mean 16 mmol). The combination solution resulted in significantly improved urea (+41%) and creatinine (+26%) clearances compared with 7.5% icodextrin. CONCLUSION: A solution containing both crystalloid (glucose 2.61%) and colloid (icodextrin 6.8%) osmotic agents enhanced fluid removal by twofold and sodium removal by threefold compared with 7.5% icodextrin solution during a dwell of 15 hours, indicating that such a combination solution could represent a new treatment option for anuric peritoneal dialysis patients with high peritoneal solute transport rate.
机译：背景：在腹膜溶质转运率高的腹膜透析患者中​​，液体和钠的去除通常不足，尤其是当残余肾功能下降时。方法：我们研究了同时使用晶体（葡萄糖）和胶体（艾考糊精）渗透剂在3.85％葡萄糖，7.5％艾考糊精， 7例腹膜透析患者腹膜溶质转运速度快，联合使用含2.61％葡萄糖和6.8％艾考糊精的混合液。结果：相较于7.5％的艾考糊精（平均净超滤462 mL，平均净钠去除49 mmol），组合流体增强了净超滤（平均990 mL）和钠去除（平均158 mmol）。相比之下，基于3.86％葡萄糖的溶液产生的超滤（平均-85 mL）和钠去除（平均16 mmol）可忽略不计。与7.5％的艾考糊精相比，该组合溶液的尿素（+ 41％）和肌酐（+ 26％）清除率显着提高。结论：在15个小时的停留时间内，与7.5％的艾考糊精溶液相比，同时含有晶体（葡萄糖2.61％）和胶体（艾考糊精6.8％）渗透剂的溶液与7.5％的艾考糊精溶液相比，其液体去除率提高了两倍，钠去除率提高了三倍。可能是高腹膜溶质转运率的无尿腹膜透析患者的一种新的治疗选择。

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