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首页> 外文期刊>Peritoneal dialysis international: Journal of the International Society for Peritoneal Dialysis >Abnormalities of body composition in peritoneal dialysis patients.
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Abnormalities of body composition in peritoneal dialysis patients.

机译：腹膜透析患者的身体成分异常。

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OBJECTIVES: Body composition changes occur in peritoneal dialysis (PD) due to abnormalities in nutrition and hydration. We investigated abnormalities of nutrition and hydration in PD patients compared with healthy controls by measurement of total body potassium (TBK) and body water compartments. DESIGN: Cross-sectional comparison study. METHODS: We measured TBK--an indicator of body cell mass--by whole body counting, total body water (TBW) by deuterium oxide dilution, and extracellular water (ECW) by bromide dilution in 29 PD patients and 32 controls. RESULTS: The absolute mean value of TBK for PD patients was not significantly lower than in controls. The ratios of observed TBK to predicted TBK from prediction formulas were compared. Equations used were those of Boddy, Bruce, Burkinshaw, and Ellis and our own equation derived from a local control database (Leeds). Observed/predicted ratios of TBK were significantly less in PD than in control subjects for all equations. Water volumes did not differ between PD and control groups. Observed/predicted ratios for TBK in PD patients correlated with serum potassium (Boddy r = 0.355, p = 0.06; Bruce r = 0.411, p < 0.05; Burkinshaw r = 0.457, p < 0.01; Leeds r = 0.412, p < or = 0.05; Ellis r = 0.356, p = 0.06) and tended to correlate with serum albumin (Bruce r = 0.343, p = 0.07; Burkinshaw r = 0.421, p < 0.05; Leeds r = 0.357, p = 0.06; Ellis r = 0.310, p = NS). There was no relationship with serum potassium in controls. Serum albumin in PD correlated with TBK (r = 0.445, p < 0.02), TBK/height (r = 0.419, p < 0.05), TBK/weight (r = 0.554, p = 0.002), and TBK/TBW (r = 0.586, p = 0.0001). Extracellular water/intracellular water (ECW/ICW) was inversely related to TBK (r = -0.455, p < 0.02 in PD; r = -0.387, p < 0.05 in controls) and to TBK/height (r = -0.446, p < 0.02 in PD; r = -0.411, p = 0.02 in controls). TBK/weight reduced with age in PD (r = -0.445, p < 0.02), as did TBK/TBW in PD (r = -0.463, p < 0.02). ECW/ICW tended to increase with age in PD (r = 0.351, p = 0.06). CONCLUSIONS: Observed/predicted ratio of TBK is reduced in PD patients relative to healthy controls, indicating reduced body cell mass. Serum albumin and potassium reflect TBK indices in PD. Body water volumes did not differ between PD and controls, implying no overall abnormality in hydration in the PD group. However, ECW is relatively increased compared to ICW with decreasing TBK indices, suggesting relative ECW expansion with reduction in body cell mass.
机译：目的：由于营养和水合作用异常，腹膜透析（PD）发生身体成分变化。我们通过测量全身钾（TBK）和身体水室来调查PD患者与健康对照相比营养和水合异常。设计：横断面比较研究。方法：我们在29名PD患者和32名对照中通过全身计数，通过氘化氘稀释的全身水（TBW）和通过溴化物稀释的细胞外水（ECW）来测量TBK（人体细胞质量的指标）。结果：PD患者的TBK绝对平均值没有显着低于对照组。比较了从预测公式中观察到的TBK与预测TBK的比率。使用的方程式是Boddy，Bruce，Burkinshaw和Ellis的方程式，以及我们自己的从局部控制数据库（利兹）衍生的方程式。在所有方程中，PD的观察/预测的TBK比率均显着低于对照组。 PD和对照组之间的水量没有差异。 PD患者中TBK的观察/预测比率与血钾相关（Boddy r = 0.355，p = 0.06; Bruce r = 0.411，p <0.05; Burkinshaw r = 0.457，p <0.01; Leeds r = 0.412，p <或= 0.05; Ellis r = 0.356，p = 0.06）并倾向于与血清白蛋白相关（Bruce r = 0.343，p = 0.07; Burkinshaw r = 0.421，p <0.05; Leeds r = 0.357，p = 0.06; Ellis r = 0.310 ，p = NS）。与对照组中的血钾无关。 PD中的血清白蛋白与TBK（r = 0.445，p <0.02），TBK /身高（r = 0.419，p <0.05），TBK /体重（r = 0.554，p = 0.002）和TBK / TBW（r = 0.586，p = 0.0001）。细胞外水/细胞内水（ECW / ICW）与TBK成反比（r = -0.455，p <0.02在PD中; r = -0.387，p <0.05在对照中）和TBK / height（r = -0.446，p在PD中<0.02;在对照组中r = -0.411，p = 0.02）。 PD的TBK /体重随年龄的增长而降低（r = -0.445，p <0.02），PD的TBK / TBW随年龄增长（r = -0.463，p <0.02）。 ECW / ICW倾向于随着PD年龄的增加而增加（r = 0.351，p = 0.06）。结论：相对于健康对照，PD患者的TBK的观察/预测比例降低，表明体细胞质量降低。血清白蛋白和钾反映PD中的TBK指数。 PD和对照组之间的身体水量没有差异，这意味着PD组的水合作用没有总体异常。但是，与TBK指数降低的ICW相比，ECW相对增加，表明相对ECW的扩张伴随着体细胞数量的减少。

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