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首页> 外文期刊>Urologic oncology >Proton therapy for prostate cancer: The initial Loma Linda University experience Slater JD, Rossi CJ Jr, Yonemoto LT, Bush DA, Jabola BR, Levy RP, Grove RI, Preston W, Slater JM, Department of Radiation Medicine, Loma Linda University Medical Center,
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Proton therapy for prostate cancer: The initial Loma Linda University experience Slater JD, Rossi CJ Jr, Yonemoto LT, Bush DA, Jabola BR, Levy RP, Grove RI, Preston W, Slater JM, Department of Radiation Medicine, Loma Linda University Medical Center,

机译：前列腺癌的质子治疗：最初的洛马琳达大学医学博士，斯洛特JD，罗西CJ，米本LT，布什DA，Jabola BR，列维RP，格罗夫RI，普雷斯顿W，斯莱特JM，洛马琳达大学医学中心放射医学系，

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PURPOSE: We analyzed results of conformal proton radiation therapy for localized prostate cancer, with emphasis on biochemical freedom from relapse. METHODS AND MATERIALS: Analyses were performed for 1255 patients treated between October 1991 and December 1997. Outcomes were measured on primarily in terms of biochemical relapse and toxicity. RESULTS: The overall biochemical disease-free survival rate was 73%, and was 90% in patients with initial PSA 4.0; it was 87% in patients with posttreatment PSA nadirs 0.50. Rates dropped with rises in initial and nadir PSA values. Long-term survival outcomes were comparable with those reported for other modalities intended for cure. CONCLUSIONS: Conformal proton radiation therapy at the reported dose levels yielded disease-free survival rates comparable with other forms of local therapy, and with minimal morbidity. Dose-escalation strategies are being implemented to further improve long-term results.
机译：目的：我们分析了局部前列腺癌的适形质子放射治疗的结果，重点是生化无复发。方法和材料：对1991年10月至1997年12月间接受治疗的1255例患者进行了分析。结果主要根据生化复发和毒性进行测定。结果：总体生化无病生存率为73％，初始PSA 4.0的患者为90％。 PSA治疗后最低值0.50的患者为87％。费率随着PSA初始值和最低值的升高而下降。长期生存结果与拟用于治疗的其他方式的报道相当。结论：在所报道的剂量水平上，适形质子放射疗法产生的无病生存率与其他形式的局部疗法相当，且发病率最低。正在实施剂量递增策略以进一步改善长期结果。

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