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首页> 外文期刊>Peritoneal dialysis international: Journal of the International Society for Peritoneal Dialysis >Intraperitoneal hyaluronan production in stable continuous ambulatory peritoneal dialysis patients.
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Intraperitoneal hyaluronan production in stable continuous ambulatory peritoneal dialysis patients.

机译：稳定连续非卧床腹膜透析患者的腹​​膜透明质酸产生。

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OBJECTIVE: Several cytokines and proteins are excreted intraperitoneally during the course of peritonitis and stable states in continuous ambulatory peritoneal dialysis (CAPD) patients. Dialysate hyaluronan (HYA) is also regarded as a marker of peritoneal healing during bacterial peritonitis. We examined here, intraperitoneal HYA production in stable CAPD patients and compared the results to those of the peritoneal equilibration test (PET), the length of time on dialysis, and other marker proteins. DESIGN: We determined the concentration of HYA and other marker proteins in the 4-hour-dwell dialysate at 1-year intervals. SETTING: CAPD unit in Hitachi General Hospital. PATIENTS: The subjects were 46 stable CAPD patients who underwent 104 PETs. RESULTS: A correlation was found between the length of time on dialysis and the amount of HYA excretion in the 4-hr-dwell dialysate (r = 0.403, p < 0.001). A positive but weak correlation was found between the dialysate-to-plasma ratio of the creatinine concentration and dialysate HYA excretion (r = 0.229, p < 0.05). Seven patients were over the 90th percentile in both the concentration of HYA (>349.2 ng/mL) and the amount of HYA (>743.6 microg/4-hr dwell). Five patients exceeded 1000 microg of HYA excretion in the 4-hr-dwell dialysate, 4 of whom showed an abrupt increase of HYA excretion to more than 1000 microg/4-hr dwell, and discontinued CAPD within 6 months due to ultrafiltration failure. Two of these 4 patients were diagnosed with sclerosing encapsulating peritonitis at autopsy. CONCLUSION: Intraperitoneal HYA production increased with both higher permeable membrane and the length of time on CAPD. Monitoring of HYA in the peritoneal dialysate may be useful as a marker to assess functional and morphological changes in the peritoneum in long-term CAPD patients.
机译：目的：在连续性非卧床腹膜透析（CAPD）患者的腹膜炎和稳定状态过程中，腹膜内会分泌几种细胞因子和蛋白质。透析液透明质酸（HYA）也被视为细菌性腹膜炎期间腹膜愈合的标志。我们在这里检查了稳定CAPD患者的腹膜内HYA产生，并将结果与​​腹膜平衡测试（PET），透析时间和其他标记蛋白的结果进行了比较。设计：我们确定了每隔1年间隔4小时的透析液中HYA和其他标记蛋白的浓度。地点：日立综合医院的CAPD病房。患者：受试者为46例稳定的CAPD患者，接受了104例PET。结果：透析时间长短与4小时透析液中HYA的排泄量之间存在相关性（r = 0.403，p <0.001）。肌酐浓度的透析液与血浆之比与透析液HYA排泄之间存在正相关但较弱的相关性（r = 0.229，p <0.05）。七名患者的HYA浓度（> 349.2 ng / mL）和HYA量（> 743.6 microg / 4-hr dwell）均超过90％。 5例患者在4小时停留透析液中的HYA排泄量超过1000微克，其中4名患者出现了HYA排泄突然增加到1000微克/ 4小时以上的留置量，并且由于超滤失败而在6个月内停用了CAPD。这4例患者中有2例在尸检时被诊断为硬化性包膜性腹膜炎。结论：随着CAPD时间的延长，腹膜HYA的产生随着渗透膜的增加和时间的增加而增加。腹膜透析液中HYA的监测可用作评估长期CAPD患者腹膜功能和形态变化的标志物。

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