Life after failure of traditional androgen deprivation therapy

Paul Schellhammer

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Life after failure of traditional androgen deprivation therapy

机译：传统雄激素剥夺疗法失败后的生活

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Castrate resistant prostate cancer is a disease state which, counterintuitively, can be successfully treated with additional therapy directed at inhibition of androgen synthesis and/or interfering with the activity of the androgen receptor. Novel androgen biosynthesis inhibitors and antiandrogens are now being tested in large phase 3 clinical trials to clarify their role in the treatment of men who have failed traditional medical castration, with or without currently available nonsteroidal antiandrogens. A renewed interest in studying parenteral delivery of estrogens may provide evidence to revisit the initial medical therapy for advancing prostate cancer.

机译：与直觉相反，去势抵抗性前列腺癌是可以通过针对抑制雄激素合成和/或干扰雄激素受体活性的其他疗法成功治疗的疾病状态。新型雄激素生物合成抑制剂和抗雄激素现在正在大型3期临床试验中进行测试，以阐明其在治疗传统药物去势失败的男性中的作用，无论是否使用目前可用的非甾体类抗雄激素。对研究胃肠外递送雌激素的重新兴趣可能提供证据，以重新审视用于推进前列腺癌的初始药物治疗。

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《Urologic oncology》 |2012年第4期|共5页
作者
Paul Schellhammer;
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正文语种 eng
中图分类泌尿科学（泌尿生殖系疾病）;
关键词
Castrate resistant prostate cancer; Androgen biosynthesis inhibitors; Anti-androgens; Estrogen;

机译：去势抵抗性前列腺癌;雄激素生物合成抑制剂;抗雄激素;雌激素;

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1. Life after failure of traditional androgen deprivation therapy [J] . Paul Schellhammer Urologic oncology . 2012,第4Suppla4期

机译：传统雄激素剥夺疗法失败后的生活
2. The addition of low-dose-rate brachytherapy and androgen-deprivation therapy decreases biochemical failure and prostate cancer death compared with dose-escalated external-beam radiation therapy for high-risk prostate cancer [J] . Shilkrut Mark, Merrick Gregory S., McLaughlin P. William, Cancer: A Journal of the American Cancer Society . 2013,第3期

机译：低剂量率近距离放射疗法和雄激素剥夺疗法的加入与高风险前列腺癌的剂量递增外照射疗法相比，减少了生化衰竭和前列腺癌的死亡
3. The addition of low-dose-rate brachytherapy and androgen-deprivation therapy decreases biochemical failure and prostate cancer death compared with dose-escalated external-beam radiation therapy for high-risk prostate cancer [J] . Shilkrut Mark, Merrick Gregory S., McLaughlin P. William, Cancer: A Journal of the American Cancer Society . 2013,第3期

机译：与高风险前列腺癌的外束辐射治疗相比，添加低剂量速率近距离放射治疗和雄激素剥夺治疗降低了生物化学衰竭和前列腺癌死亡
4. Serum levels of sex hormones before and after androgen deprivation therapy in Japanese prostate cancer patients [C] . A. Komiya, K. Ichimatsu, A. Morii, International Congress of Andrology . 2009

机译：日本前列腺癌患者中雄激素剥夺治疗前后的性激素血清水平
5. Impact of androgen deprivation therapy on quality of life in men with stage IV prostate cancer. [D] . Withrow, Susanne. 2016

机译：雄激素剥夺治疗对IV期前列腺癌男性生活质量的影响。
6. Efficacy and safety of keishibukuryogan a traditional Japanese Kampo medicine for hot flashes in prostate cancer patients receiving androgen deprivation therapy [O] . Kazuyoshi Shigehara, Kouji Izumi, Kazufumi Nakashima, 2020

机译：keishibukuryogan一种传统的日本kampo医学在前列腺癌患者接受雄激素剥夺治疗的潮流闪烁的疗效和安全性
7. The addition of low‐dose‐rate brachytherapy and androgen‐deprivation therapy decreases biochemical failure and prostate cancer death compared with dose‐escalated external‐beam radiation therapy for high‐risk prostate cancer [O] . Shilkrut, Mark, Merrick, Gregory S., McLaughlin, P. William, 2013

机译：低剂量率近距离放射治疗和雄激素剥夺疗法的加入减少了生化失败和前列腺癌死亡与高风险前列腺癌的剂量递增外束放射治疗相比
8. Hot Flashes among Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: Psychosocial and Quality of Life Issues [R] . Coyne, J. , Vaughn, D. J. , Dinges, D. , 2006

机译：接受雄激素剥夺治疗的前列腺癌患者的热潮：心理社会和生活质量问题

Life after failure of traditional androgen deprivation therapy

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