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首页> 外文期刊>Chemistry: A European journal >Integrated palladium-catalyzed arylation of heavier groupa 14 hydrides
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Integrated palladium-catalyzed arylation of heavier groupa 14 hydrides

机译：较重的Groupa 14氢化物的集成钯催化芳基化

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摘要

A convenient procedure has been developed for the preparation of Groupa 14 compounds by integrated palladium-catalyzed cross-coupling of aromatic iodides with the corresponding Groupa 14 hydrides in the presence of a base. The reaction conditions can be applied to the cross-coupling of tertiary, secondary, and primary Groupa 14 compounds. In most cases, the desired arylated products were obtained in synthetically useful yields. Even in the case of aryl iodides containing OH, NH_2, CN, or CO_2R groups, the reactions proceeded with good to high yields with tolerance of these reactive functional groups. A possible application of this method is the unique synthesis of a fungicidal diarylmethyl(1H-1,2,4-triazol-1-ylmethyl)silane derivative. A convenient procedure has been developed for the preparation of Groupa 14 compounds by integrated palladium-catalyzed cross-coupling of aromatic iodides with the corresponding Groupa 14 hydrides in the presence of a base (see picture). Application of this method in the synthesis of a fungicidal diarylmethyl(1H-1,2,4-triazol-1-yl-methyl)silane derivative is demonstrated.
机译：已经开发了一种在碱的存在下通过芳族碘化物与相应的Groupa 14氢化物的钯催化交叉偶联的整体制备制备Groupa 14化合物的简便方法。该反应条件可以应用于叔，仲和伯Group 14化合物的交叉偶联。在大多数情况下，所需的芳基化产物以合成有用的产率获得。即使在含有OH，NH_2，CN或CO_2R基团的芳基碘化物的情况下，反应也可以以良好的产率进行，并且对这些反应性官能团具有耐受性。该方法的可能应用是独特的杀真菌二芳基甲基（1H-1,2,4-三唑-1-基甲基）硅烷衍生物的合成。已经开发了一种方便的方法，用于在碱存在下，通过钯催化的芳族碘化物与相应的Groupa 14氢化物的交叉偶联，制备Groupa 14化合物（参见图片）。证明了该方法在杀真菌二芳基甲基（1H-1,2,4-三唑-1-基-甲基）硅烷衍生物的合成中的应用。

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