Highly Efficient Access to Bi- and Tricyclic Ketals through Gold-Catalyzed Tandem Reactions of 4-Acyl-1,6-diynes

Meng J; Zhao YL; Ren CQ; Li Y; Li Z; Liu Q

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Highly Efficient Access to Bi- and Tricyclic Ketals through Gold-Catalyzed Tandem Reactions of 4-Acyl-1,6-diynes

机译：通过金催化的4-Acyl-1,6-diynes串联反应高效获得双环和三环缩酮

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Single step: Fused bicyclic and bridged tricyclic ketals were synthesized in a single step from the reactions of easily available 4-acyl-1,6-diynes with H2O and alkanols (see scheme). The highly efficient AuCl3-catalyzed multicomponent domino reactions, involving five C-O bond formations, can proceed in a highly regio- and diastereoselective manner at room temperature under air and lead to structures of high molecular complexity from simple starting materials in an atom economic way.

机译：一步：从容易获得的4-酰基-1,6-二炔与水和烷醇的反应中一步合成熔融的双环和桥联的三环缩酮（参见方案）。涉及五个C-O键形成的高效AuCl3催化的多组分多米诺骨牌反应可以在室温下在空气中以高度区域和非对映选择性的方式进行，并以原子经济的方式从简单的起始原料导致结构复杂的分子。

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《Chemistry: A European journal》 |2009年第8期|共5页
作者
Meng J; Zhao YL; Ren CQ; Li Y; Li Z; Liu Q;
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正文语种 eng
中图分类化学;
关键词
asymmetric synthesis; cyclization; domino reactions; gold; ONE-POT SYNTHESIS; KETALIZATION/RING-CLOSING METATHESIS; C BOND FORMATION; SUBSTITUTED FURANS; BICYCLIC ACETALS; KETENE DITHIOACETALS; SYNTHETIC STRATEGY; 5C+1N ANNULATION; DOMINO REACTIONS; MILD CONDITIONS;

机译：不对称合成;环化;多米诺反应;金;一锅合成;开环/闭环复分解;C键形成;取代的呋喃;双环乙酸;丁烯二缩醛;合成策略;5C + 1N环化;多米诺反应;

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1. Highly Efficient Access to Bi- and Tricyclic Ketals through Gold-Catalyzed Tandem Reactions of 4-Acyl-1,6-diynes [J] . Meng J, Zhao YL, Ren CQ, Chemistry: A European journal . 2009,第8期

机译：通过金催化的4-Acyl-1,6-diynes串联反应高效获得双环和三环缩酮
2. Gold-catalyzed tandem reaction of 2-alkynylanilines followed by 1,6-conjugate addition to p-quinone methides: efficient access to unsymmetrical diarylindolylmethanes [J] . Raveendra Jillella, Dong hwan Oh, Chang Ho Oh New Journal of Chemistry . 2018,第20期

机译：2-炔基胺的金催化串联反应，然后加入1,6-缀合物加入p-醌甲基氨甲酸酯：有效进入不对称二芳基甲基甲烷基甲烷
3. Mechanochemical Grinding Diels-Alder Reaction: Highly Efficient and Rapid Access to Bi-, Tri-, and Tetracyclic Systems [J] . Agarwal Jyoti, Rani Rashmi, Peddinti Rama Krishna Synlett . 2017,第11期

机译：机械化学研磨Diels-Alder反应：对Bi-，Tri-and和四环系统的高效和快速获得
4. Gold-Catalyzed Synthesis of Polycyclic Enones from Carbon Tethered 1,3-Enynyl Carbonyls via Tandem Heteroenyne Metathesis and Nazarov Reaction [C] . Tienan Jin, Yoshinori Yamamoto Symposium on Organometallic Chemistry . 2008

机译：通过串联杂肾复分解和纳氮化反应，金催化来自碳系丝的1,3-烯基羰基的多环肿块的合成
5. Transition metal-catalyzed tandem carbon-oxygen and carbon-carbon bond forming reactions of alkynes in (1) the addition-cyclization of carboxylic acids with 1,6-diynes and in (2) the total synthesis of frondosin B. [D] . Goble, Stephen D. 2006

机译：炔烃的过渡金属催化串联碳-氧和碳-碳键形成反应在（1）羧酸与1,6-二炔的加成环化中和（2）frondosin B的总合成中。
6. Efficient access to sp3-rich tricyclic amine scaffolds through Diels-Alder reactions of azide-containing silyloxydienes [O] . Michael C. McLeod, Jeffrey Aubé -1

机译：通过含叠氮化物的甲硅烷氧基二烯的Diels-Alder反应有效地获得富含sp3的三环胺骨架
7. Highly Efficient Access to Strained Bicyclic Ketals via Gold-Catalyzed Cycloisomerization of Bis-homopropargylic Diols [O] . -1

机译：通过黄金催化的双相丙基二醇的金催化环机化高效地获得紧张双环酮
8. Novel Wide Band Gap Materials for Highly Efficient thin Film Tandem Solar Cells, (Final Report). [R] . Peters, C., Connor, S. 2011

机译：用于高效薄膜串联太阳能电池的新型宽带隙材料，（最终报告）。

Highly Efficient Access to Bi- and Tricyclic Ketals through Gold-Catalyzed Tandem Reactions of 4-Acyl-1,6-diynes

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