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Synthesis of n-Butyl Acrylate Copolymers for Medical Adhesives

机译:医用胶粘剂丙烯酸正丁酯共聚物的合成

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摘要

The testing results for copolymers of n-butyl acrylate with N-vinylsuccinimide used as medical adhesive materials are presented.These adhesives are designed to provide for the needed mechanical strength and also to be a conductor of physiologically active compounds.The copolymers under consideration are able to immobilize drugs containing amine groups.It is shown experimentally that vinylsuccinimide units in the copolymers with butyl acrylate can be easily and selectively transformed by alkali hydrolysis(without involving acrylate units)into units of N-vinylsuccinamic acid containing carboxyl groups,which makes it possible to immobilize physiologically active compounds on a polymer matrix such as this.
机译:给出了丙烯酸正丁酯与N-乙烯基琥珀酰亚胺作为医用胶粘剂的共聚物的测试结果,这些胶粘剂旨在提供所需的机械强度,并可以作为生理活性化合物的导体。实验证明,与丙烯酸丁酯的共聚物中的乙烯基琥珀酰亚胺单元可通过碱水解(不涉及丙烯酸酯单元)轻松,选择性地转化为含羧基的N-乙烯基琥珀酰胺酸单元,这使其成为可能。将生理活性化合物固定在这样的聚合物基质上。

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