A general access to zaragozic acids: Total synthesis and structure elucidation of zaragozic acidD and formal syntheses of zaragozic acidsA and C

Wang Y.; Metz P.

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A general access to zaragozic acids: Total synthesis and structure elucidation of zaragozic acidD and formal syntheses of zaragozic acidsA and C

机译：普遍使用zaragozic酸的方法：zaragozic acidD的总合成和结构解析以及zaragozic acidA和C的形式合成

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One for all: The 2,8-dioxabicyclo[3.2.1]octane derivative 1 served as a general building block for the bioactive title compounds (see scheme; Bz=benzoyl, Bn=benzyl). Two chemoselective alkynylations and two ruthenium-catalyzed hydrogenations had key roles in the first total synthesis of zaragozic acidD, a potent ras-farnesyl protein transferase inhibitor.

机译：唯一的一个：2,8-二氧杂双环[3.2.1]辛烷衍生物1用作生物活性标题化合物的一般结构单元（请参见方案; Bz =苯甲酰基，Bn =苄基）。两个化学选择性的炔基化和两个钌催化的氢化作用在首个全合成的有效的ras-法呢基蛋白转移酶抑制剂zaragozic acidD的合成中起着关键作用。

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《Chemistry: A European journal》 |2011年第12期|共3页
作者
Wang Y.; Metz P.;
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正文语种 eng
中图分类应用化学;
关键词
alkynylation; asymmetric catalysis; chemoselectivity; natural products; total synthesis;

机译：炔基化;不对称催化;化学选择性;天然产物;全合成;

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1. A general access to zaragozic acids: Total synthesis and structure elucidation of zaragozic acidD and formal syntheses of zaragozic acidsA and C [J] . Wang Y., Metz P. Chemistry: A European journal . 2011,第12期

机译：普遍使用zaragozic酸的方法：zaragozic acidD的总合成和结构解析以及zaragozic acidA和C的形式合成
2. Formal Total Synthesis of(+)-Zaragozic Acid C through an Ireland-Claisen Rearrangement** [J] . Jens O.Bunte, Anthony N.Cuzzupe, Alica M.Daly Angewandte Chemie . 2006,第38期

机译：通过爱尔兰-克莱森重排形式的（+）-Zaragozic酸C的正式全合成**
3. Total syntheses of zaragozic acids A and C by a carbonyl ylide cycloaddition strategy [J] . Hirata Y, Nakamura S, Watanabe N, Chemistry: A European journal . 2006,第35期

机译：通过羰基内酯环加成策略合成zaragozic酸A和C
4. A symmetry-based approach to the heterobicyclic core of the zaragozic acids [C] . Sylvia Gang, Peter Metz European Symposium on Organic Chemistry . 2009

机译：基于对称的Zaragozic酸异质环核的方法
5. I. [1,2]-Brook rearrangement: Application of silyl glyoxylates in a novel glycolate aldol reaction and in a controlled oligomerization to complete the total synthesis of zaragozic acid C. II. Progress toward the total synthesis of pactamycin. [D] . Satterfield, Andrew Duncan. 2009

机译：I. [1,2]-布鲁克重排：甲硅烷基乙氧基化物在新型乙醇酸酯羟醛反应中和可控的低聚反应中的应用，以完成zaragozic酸C的总合成。向全合成pactamycin的进展。
6. Alkylation of lithiated dimethyl tartrate acetonide with unactivated alkyl halides and application to an asymmetric synthesis of the 28-dioxabicyclo3.2.1octane core of squalestatins/zaragozic acids [O] . Herman O Sintim, Hamad H Al Mamari, Hasanain A A Almohseni, 2019

机译：锂化的酒石酸二甲酯二丙酮化物与未活化的烷基卤化物的烷基化及其在角鲨素/芥子酸的28-二氧杂双环3.2.1辛烷核的不对称合成中的应用
7. Total Synthesis of Zaragozic Acid C [O] . 2017

机译：Zaragozic酸C的总合成
8. Dibutylphosphoric acid synthesis. (Synthese de l'acide dibutylphosphorique) [R] . Elias, H. , Boumaout, R. , Kellou, N. , 1995

机译：二丁基磷酸合成。（synthese de l'acide dibutylphosphorique）

A general access to zaragozic acids: Total synthesis and structure elucidation of zaragozic acidD and formal syntheses of zaragozic acidsA and C

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