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首页> 外文期刊>Chemistry: A European journal >The microwave-to-flow paradigm: Translating high-temperature batch microwave chemistry to scalable continuous-flow processes
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The microwave-to-flow paradigm: Translating high-temperature batch microwave chemistry to scalable continuous-flow processes

机译：微波到流的范例：将高温批处理微波化学转化为可扩展的连续流过程

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摘要

The popularity of dedicated microwave reactors in many academic and industrial laboratories has produced a plethora of synthetic protocols that are based on this enabling technology. In the majority of examples, transformations that require several hours when performed using conventional heating under reflux conditions reach completion in a few minutes or even seconds in sealed-vessel, autoclave-type, microwave reactors. However, one severe drawback of microwave chemistry is the difficulty in scaling this technology to a production-scale level. This Concept article demonstrates that this limitation can be overcome by translating batch microwave chemistry to scalable continuous-flow processes. For this purpose, conventionally heated micro- or mesofluidic flow devices fitted with a back-pressure regulator are employed, in which the high temperatures and pressures attainable in a sealed-vessel microwave chemistry batch experiment can be mimicked. Microwaves not required! Conventionally heated flow reactors (coils or chips) fitted with back-pressure regulators can mimic the high temperatures and pressures attainable in a sealed-vessel microwave instrument. Such devices can therefore be used to perform otherwise difficult to scale microwave chemistry (see scheme).
机译：专用微波反应器在许多学术和工业实验室中的普及已经产生了许多基于这种使能技术的合成方案。在大多数示例中，在回流条件下使用常规加热进行时需要几个小时的转化才能在密封容器，高压釜型微波反应器中在几分钟甚至几秒钟内完成。然而，微波化学的一个严重缺点是难以将该技术规模化至生产规模。此概念文章证明，可以通过将批处理微波化学转化为可扩展的连续流过程来克服此限制。为此目的，使用装配有背压调节器的常规加热的微流体或介流体流动装置，其中可以模拟密封容器微波化学批量实验中可获得的高温和高压。不需要微波炉！常规地，配备有背压调节器的加热流反应器（线圈或碎屑）可以模仿密封容器微波仪器中可达到的高温和高压。因此，此类设备可用于执行难以按比例缩放的微波化学反应（请参见方案）。

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