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首页> 外文期刊>Polymer: The International Journal for the Science and Technology of Polymers >BIODEGRADABLE BRUSH-LIKE GRAFT POLYMERS FROM POLY(D,L-LACTIDE) OR POLY(D,L-LACTIDE-CO-GLYCOLIDE) AND CHARGE-MODIFIED, HYDROPHILIC DEXTRANS AS BACKBONE - SYNTHESIS, CHARACTERIZATION AND IN VITRO DEGRADATION PROPERTIES
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BIODEGRADABLE BRUSH-LIKE GRAFT POLYMERS FROM POLY(D,L-LACTIDE) OR POLY(D,L-LACTIDE-CO-GLYCOLIDE) AND CHARGE-MODIFIED, HYDROPHILIC DEXTRANS AS BACKBONE - SYNTHESIS, CHARACTERIZATION AND IN VITRO DEGRADATION PROPERTIES

机译：聚（D，L-丙交酯）或聚（D，L-丙交酯-乙交酯）的生物可降解刷状接枝聚合物，以及作为主链的电荷改性亲水性右旋糖酐-合成，表征和体外降解

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摘要

Brush-like graft polylactide (PLA) and poly(lactide-co-glycolide) (PLG) containing water soluble charged dextrans: dextran sulphate sodium (DSS) and diethylaminoethyl dextran chloride (DEAED) as backbones were synthesized in a bulk polymerization reaction using stannous octoate as catalyst. The polymers were characterized by n.m.r., g.p.c., LS, intrinsic viscosity measurement and d.s.c. methods. Brush-like graft PLA and PLG have different physico-chemical properties compared to linear polyesters such as PLA and PLG. Significantly accelerated degradation properties of the graft polymers were observed compared to linear PLG. A rapid decrease in polymer molecular weight and polymer mass demonstrates the influence of charged functionalities in the backbone. The nonlinear chain structure and an increased number of polar end groups accelerate the degradation and the apparent mass loss of the brush-like graft PLG when the weight average molecular weight (M-w) is still higher suggests a different mechanism from that of linear PLG. The polar groups in the polymeric backbone facilitate the cleavage of ester bonds. A discontinuous polymer mass loss in the case of linear PLG was not observed for brush-like graft polyesters. The charged polyelectrolyte backbone may also anew higher drug loading of parenteral delivery system with peptides and proteins due to ironic interactions. (C) 1997 Elsevier Science Ltd. [References: 33]
机译：使用亚锡酸在本体聚合反应中合成了含有水溶性带电右旋糖酐：右旋糖酐硫酸钠（DSS）和二乙氨基乙基右旋糖酐氯化物（DEAED）的刷子状接枝聚丙交酯（PLA）和聚丙交酯-乙交酯共聚物（PLG）。辛酸酯为催化剂。通过n.m.r.，g.p.c.，LS，特性粘度测量和d.s.c.对聚合物进行表征。方法。与线性聚酯（例如PLA和PLG）相比，刷状接枝PLA和PLG具有不同的物理化学性质。与线性PLG相比，观察到接枝聚合物的明显加速降解性能。聚合物分子量和聚合物质量的快速降低证明了主链中带电官能团的影响。当重均分子量（M-w）仍然更高时，非线性链结构和增加的极性端基数量会加速降解，并且刷状接枝PLG的表观质量损失表明与线性PLG的机理不同。聚合物主链中的极性基团促进酯键的裂解。对于刷状接枝聚酯，在线性PLG的情况下未观察到不连续的聚合物质量损失。带电荷的聚电解质主链也可能由于具有讽刺性的相互作用而使具有肽和蛋白质的肠胃外递送系统的药物负荷更高。 （C）1997 Elsevier Science Ltd. [参考：33]

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