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首页> 外文期刊>Chemistry: A European journal >Supramolecular Self-Assembing Properties of Membrane-Spanning Archaeal Tetraether Glycolipid Analogues
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Supramolecular Self-Assembing Properties of Membrane-Spanning Archaeal Tetraether Glycolipid Analogues

机译：跨膜古细菌四醚糖脂类似物的超分子自组装特性

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摘要

The self-assembling propoerties of a new series of archeal tetraether glycolipid analogues 1-6 that are characterized by a bipolar architecture with two similar or different glycosiic and/or phosphate polar heads and a lipid core possessing a cyclopentane unit and/or branched chains were studied by means of differential scanning calorimetry, optical micrroscopy, X-ray scattering, freeze-fracture electron microscopy and dynamic light scattering. Unsymmetrical phosphate derivatives 1 and 2 spontaneously formed thermostable multilamellar and unilamellar vesicles in whihc most of the bipolar lipids adopted a trans-membrane conformation, as revealed by freeze-fracture electron microscopy. Supramolecular aggregates of neutral glyxolipids 3-6 were found to depend on both the saccharidic polar heads and the chain composition. The presence of one glyxosidic residue with rather marked hydrophilic properties, such aas the lactosyl moiety , was required to allow the formation of multilamellar vesicles. Surprisingly , the introduction of a cyclopentane unit in the bridging chain was able to induce an apparent two-by -two membrane association: this unusual behaviour might be the result of unsymmetrica interfacial properities of the lipid layer caused by the presence of the cyclopentane unit
机译：一系列新的古细菌四醚糖脂类似物1-6的自组装性质为双极性结构，具有两个相似或不同的糖基和/或磷酸盐极性头和具有环戊烷单元和/或支链的脂质核心。通过差示扫描量热法，光学显微术，X射线散射，冷冻断裂电子显微镜和动态光散射进行了研究。不对称的磷酸盐衍生物1和2在大多数双极性脂质中均自发形成了热稳定的多层和单层囊泡，如冷冻断裂电子显微镜所揭示的那样。发现中性糖脂3-6的超分子聚集体取决于糖性极性头和链组成。为了形成多层囊泡，需要存在一个糖苷残基具有相当明显的亲水性，例如乳糖基部分。出人意料的是，在桥连链中引入环戊烷单元能够诱导明显的两两膜结合：这种异常行为可能是由于环戊烷单元的存在导致脂质层界面性质不对称的结果。

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