Multi-Step Application of Immobilized Reagents and Scavengers:A Total Synthesis of Epothilone C

R.Ian Storer; Toshiyasu Takemoto; Philip S.Jackson; Dearg S.Brown; Ian R.Baxendale; Steven V.Ley

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Multi-Step Application of Immobilized Reagents and Scavengers:A Total Synthesis of Epothilone C

机译：固定化试剂和清除剂的多步应用：埃坡霉素C的全合成

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The total synthesis of the cytotoxic antitumour natural product epothilo-ne C has provided a stage for the exploitation and further development of immobilized reagent methods.A stereoselective convergent synthetic strategy was applied,incorporating polymer-supported reagents,catalysts,scavengers and catch-and-re-lease techniques to avoid frequent aqueous work-up and chromatographic purification.

机译：细胞毒性抗肿瘤天然产物epothilonene C的全合成为固定化试剂方法的开发和进一步发展提供了一个阶段。采用了立体选择性聚合合成策略，将聚合物负载的试剂，催化剂，清除剂和捕集并入重新租赁技术，以避免频繁的水后处理和色谱纯化。

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《Chemistry: A European journal》 |2004年第10期|共19页
作者
R.Ian Storer; Toshiyasu Takemoto; Philip S.Jackson; Dearg S.Brown; Ian R.Baxendale; Steven V.Ley;
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正文语种 eng
中图分类化学;
关键词
aldol reaction; antitu-mor agents; immobilized reagents; polyketides; polymers;

机译：醛醇缩合反应;抗肿瘤药;固定化试剂;聚酮;聚合物;

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专利

1. Multi-Step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C and A [J] . J.R.Garabatos-Perera, R.I.Saez-Dia Chemtracts . 2006,第10期

机译：固定化试剂和清除剂的多步应用：埃坡霉素C和A的全合成
2. Multi-Step Application of Immobilized Reagents and Scavengers:A Total Synthesis of Epothilone C [J] . R.Ian Storer, Toshiyasu Takemoto, Philip S.Jackson, Chemistry: A European journal . 2004,第10期

机译：固定化试剂和清除剂的多步应用：埃坡霉素C的全合成
3. Huiti-Step Application of Inn mobilized Reagents and Scavengers: A Total Synthesis of Epothilone C and A [J] . J.R. Garabatos-Perera, R.I. Saez-Dlaz Chemtracts . 2006,第10期

机译：Inn动员的试剂和清除剂的Huiti步骤应用：埃坡霉素C和A的全合成
4. Synthesis of spatially addressed library of alanine dipeptides from rac-Z-Ala-OH means of sub-library of chiral triazine condensing reagents immobilized on cellulose [C] . Zbigniew J.Kaminski, Beata Kolesinska European Peptide Symposium . 2002

机译：基于纤维素的手性三嗪冷凝试剂亚文库中丙氨酸二肽的空间寻址文库的合成
5. Studies of nucleophile ring opening of oxabicyclic systems in highly polar media: Application to a total synthesis of antitumor agent, (-)-epothilone B. [D] . Diep, Nhut Kiet. 2006

机译：高极性介质中氧双环系统亲核试剂开环的研究：在抗肿瘤剂（-）-埃博霉素B的全合成中的应用。
6. DualPhos: a versatile chemoselective reagent for two-carbon aldehyde to latent (E)-alkenal homologation and application in the total synthesis of phomolide G [O] . David McLeod, James McNulty 2016

机译：DualPhos：一种多功能的化学选择试剂用于将二碳醛转化为潜在的（E）-烯键式同构物并应用于总磷光体G的合成中
7. Cover Picture: Multi-Step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C (Chem. Eur. J. 10/2004) [O] . R. Ian Storer, Toshiyasu Takemoto, Philip S. Jackson, 2004

机译：封面图片：固定化试剂和清除剂的多步施加：EPOTHILONE C（CHEM.EUR.J.10/2004）
8. Strategy Toward the Total Synthesis of Epothilones A and B [R] . Lee, C. B. , Danieshafsky, S. 2000

机译：埃博霉素a和B的全合成策略

Multi-Step Application of Immobilized Reagents and Scavengers:A Total Synthesis of Epothilone C

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