Peptide Recognition:Encapsulation and alpha-Helical Folding of a Nine-Residue Peptide within a Hydrophobic Dimeric Capsule of a Bowl-Shaped Host

Shohei Tashiro; Masahide Tominaga; Yoshiki Yamaguchi; Koichi Kato; Makoto Fujita

首页> 外文期刊>Chemistry: A European journal >Peptide Recognition:Encapsulation and alpha-Helical Folding of a Nine-Residue Peptide within a Hydrophobic Dimeric Capsule of a Bowl-Shaped Host

【24h】

Peptide Recognition:Encapsulation and alpha-Helical Folding of a Nine-Residue Peptide within a Hydrophobic Dimeric Capsule of a Bowl-Shaped Host

机译：肽识别：碗形宿主疏水二聚体胶囊中的九个残基肽的封装和α-螺旋折叠。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A dimeric capsule of coordination bowl 1 encapsulated a nine-residue peptide (Trp-Ala-Glu-Ala-Ala-Ala-Glu-Ala-Trp;2) within the large hydrophobic cavity in water,and stabilized the alpha-helical conformation of bound 2.An NMR titration experiment revealed that monomeric bowl 1 recognized two Trp residues at the both terminals of 2 through 1/2=1:1 to 2:1 complexation.The 1:1 and 2:1 species exist in equilibrium even in the presence of excess 1.It was found that the formation of the 2:1 complex,in which two bowls of 1 wrapped the whole of 2,became dominant by the addition of NaNO_3 due to the fact that the enhanced ion strength increased the hydrophobic interaction between Trp residues and the cavity of 1.The alpha-helical conformation of 2 within the dimeric capsule of 1 was elucidated from detailed NOESY analysis.

机译：配位碗1的二聚体胶囊将9个残基的肽（Trp-Ala-Glu-Ala-Ala-Ala-Glu-Ala-Trp; 2）包裹在水中的大疏水腔中，并稳定了其的α-螺旋构象结合2的NMR滴定实验表明，单体碗1在2到1/2 = 1：1到2：1络合的两个末端都识别出两个Trp残基。即使在存在过量的1。发现形成2：1的络合物，其中两碗1包裹了整个2，由于加入了NaNO_3而占优势，这是由于增强的离子强度增加了疏水性Trp残基和1的腔之间的相互作用。详细的NOESY分析阐明了1的二聚体胶囊中2的α-螺旋构象。

著录项

来源
《Chemistry: A European journal》 |2006年第12期|共7页
作者
Shohei Tashiro; Masahide Tominaga; Yoshiki Yamaguchi; Koichi Kato; Makoto Fujita;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类化学;
关键词
helical structures; host-guest systems; NMR spectroscopy; peptides; self-assembly;

机译：螺旋结构;客体系统;核磁共振光谱;肽;自组装;

相似文献

外文文献
中文文献
专利

1. Peptide Recognition:Encapsulation and alpha-Helical Folding of a Nine-Residue Peptide within a Hydrophobic Dimeric Capsule of a Bowl-Shaped Host [J] . Shohei Tashiro, Masahide Tominaga, Yoshiki Yamaguchi, Chemistry: A European journal . 2006,第12期

机译：肽识别：碗形宿主疏水二聚体胶囊中的九个残基肽的封装和α-螺旋折叠。
2. RECOGNITION OF ALPHA-HELICAL PEPTIDE STRUCTURES USING HIGHPERFORMANCE LIQUID CHROMATOGRAPHIC RETENTION DATA FOR D-AMINO ACID ANALOGUES - INFLUENCE OF PEPTIDE AMPHIPATHICITY AND OF STATIONARY PHASE HYDROPHOBICITY [J] . Rothemund S., Beyermann M., Dathe M., Journal of chromatography, A: Including electrophoresis and other separation methods . 1995,第2期

机译：使用高效液相色谱保留数据识别D-氨基酸类似物来识别α-螺旋肽结构-肽的两亲性和固定相疏水性的影响
3. Encapsulation of divalent tetrahedral oxyanions of sulfur within the rigidified dimeric capsular assembly of a tripodal receptor: First crystallographic evidence of thiosulfate encapsulation within neutral receptor capsule [J] . Basu A., Das G. Dalton transactions: An international journal of inorganic chemistry . 2012,第35期

机译：三脚架受体的刚性二聚体荚膜组件中硫的二价四面体含氧阴离子的包裹：硫代硫酸盐包裹在中性受体囊中的第一个晶体学证据
4. Peptide Intramolecular Folding into β-Hairpins and Consequent Intermolecular Self Assembly into Rigid Hydrogels: Effects of Peptide Hydrophobicity [C] . Tuna Yucel, Chris Micklitsch, Joel P. Schneider PMSE Symposia . 2005

机译：肽分子内折叠成β-发夹并随后分子间自组装成刚性水凝胶：肽疏水性的影响
5. Binding and folding of intrinsically disordered regions of proteins: Analysis of recognition elements in hemeproteins and peptides. [D] . Landfried, Daniel A. 2010

机译：蛋白质内在无序区域的结合和折叠：血红蛋白和多肽中的识别元件分析。
6. β-Hairpin Folding Mechanism of a Nine-Residue Peptide Revealed from Molecular Dynamics Simulations in Explicit Water [O] . Xiongwu Wu, Bernard R. Brooks 2004

机译：从显式水中的分子动力学模拟揭示九个肽的β-发夹折叠机制。
7. Aromatic Amino Acids Confer Folding Propensities to a Nine-Residue Peptide [O] . Bignucolo Olivier, Grzesiek Stephan, Bernèche Simon 2013

机译：芳香氨基酸赋予九个残基肽的折叠倾向。

Peptide Recognition:Encapsulation and alpha-Helical Folding of a Nine-Residue Peptide within a Hydrophobic Dimeric Capsule of a Bowl-Shaped Host

摘要

著录项

相似文献

相关主题

期刊订阅