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首页> 外文期刊>Chemistry: A European journal >Chirality Transfer from Silicon to Carbon
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Chirality Transfer from Silicon to Carbon

机译：从硅到碳的手性转移

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摘要

The exploitation of the asymmetry at silicon in stereoselective synthesis is an exceptionally challenging task.Initially,silicon-stereogenic silanes have been utilized to elucidate the stereochemical course of substitution reactions at silicon.Apart from these mechanistic investigations,only a handful of synthetic applications with an asymmetrically substituted silicon as the stereo-chemical controller have been reported to date.In these transformations the chiral silicon functions as a chiral auxiliary.Conversely,a direct transfer of chirality from silicon to carbon during bond formation and cleavage at silicon has remained open until its recent realization in both inter- and intramolecular reactions.In this Concept,the pivotal considerations in relation to the nature of suitable silanes as well as mechanistic prerequisites for an efficient chirality transfer will be discussed.
机译：立体选择性合成中硅的不对称性的利用是一项极具挑战性的任务。最初，硅立体异构硅烷已被用于阐明硅取代反应的立体化学过程。除这些机理研究外，只有少数合成应用迄今为止，已经报道了不对称取代的硅作为立体化学控制剂。在这些转变中，手性硅起手性助剂的作用。相反，手性从硅到碳的直接转移在键形成和在硅上的裂解一直保持开放直到其在该概念中，将讨论关于合适的硅烷的性质以及有效手性转移的机械先决条件的关键考虑。

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