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Platform Synthesis:A Useful Strategy for Rapid and Systematic Generation of Molecular Diversity

机译:平台综合:快速和系统地产生分子多样性的有用策略

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Emergence of library-based approaches have changed the way of developing new functional molecules in materials science and pharmaceutical science.Therefore,reliable methods for rapid and systematic generation of functional molecules are highly called for in this field.We herein describe our concept of"platform synthesis"as a useful strategy for generating molecular diversity.This simple yet powerful strategy realizes the synthesis of a number of interesting multifunctional molecules,such as multisubstituted olefins,in a programmable and diversity-oriented format.As well as applications to the synthesis of pharmaceutically important molecules,such as tamoxifen and CDP840,applications to materials science,which have led to the discovery of interesting fluorescent materials and properties,are also described.
机译:基于库的方法的出现改变了材料科学和制药科学中开发新功能分子的方式。因此,在该领域急需一种可靠,快速,系统地生成功能分子的方法。本文描述了“平台”的概念合成”是产生分子多样性的有用策略。这种简单而强大的策略以可编程且面向多样性的方式实现了许多有趣的多功能分子(如多取代的烯烃)的合成。以及在药物合成中的应用还介绍了重要的分子,如他莫昔芬和CDP840在材料科学中的应用,这些材料导致发现有趣的荧光材料和性质。

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