A hyaluronidase supercatalyst for the enzymatic polymerization to synthesize glycosaminoglycans

Kobayashi S; Ohmae M; Ochiai H; Fujikawa SI

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A hyaluronidase supercatalyst for the enzymatic polymerization to synthesize glycosaminoglycans

机译：透明质酸酶超级催化剂，用于酶促聚合反应合成糖胺聚糖

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Hyaluronidase (HAase) catalyzes multiple enzymatic polymerizations with controlling regio- and stereoselectivity perfectly. This behavior, that is, the single enzyme being effective for multireactions and retaining the enzyme catalytic specificity, is not usual, and hence, HAase is a supercatalyst. Various sugar oxazoline monomers prepared based on the concept "transition-state analogue substrate" were successfully polymerized and copolymerized with HAase catalysis, yielding natural and unnatural glycosaminoglycans.

机译：透明质酸酶（HAase）催化多种酶促聚合反应，可完美控制区域和立体选择性。这种行为，即对多种反应有效并保持酶催化特异性的单一酶并不常见，因此HAase是超催化剂。基于“过渡态类似物底物”概念制备的各种糖恶唑啉单体已通过HAase催化成功聚合并共聚，生成了天然和非天然的糖胺聚糖。

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来源
《Chemistry: A European journal》 |2006年第23期|共10页
作者
Kobayashi S; Ohmae M; Ochiai H; Fujikawa SI;
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正文语种 eng
中图分类化学;
关键词
enzyme catalysis; glycosaminoglycans; hyaluronidase; polymerization; HEPARAN-SULFATE PROTEOGLYCANS; IN-VITRO SYNTHESIS; CHONDROITIN SULFATE; POLYSACCHARIDE SYNTHESIS; SYNTHETIC CELLULOSE; NEURITE OUTGROWTH; ARTIFICIAL CHITIN; MOLECULAR-CLONING; BIOSYNTHESIS; GENES;

机译：酶催化;糖胺聚糖;透明质酸酶;聚合;肝素硫酸蛋白;体外合成;软骨素硫酸盐;多糖的合成;合成纤维素;神经胶质的产物;人工甲壳素;分子克隆;

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专利

1. A hyaluronidase supercatalyst for the enzymatic polymerization to synthesize glycosaminoglycans [J] . Kobayashi S, Ohmae M, Ochiai H, Chemistry: A European journal . 2006,第23期

机译：透明质酸酶超级催化剂，用于酶促聚合反应合成糖胺聚糖
2. Enzymatic Copolymerization to Hybrid Glycosaminoglycans: A Novel Strategy for Intramolecular Hybridization of Polysaccharides [J] . Hirofumi Ochiai, Shun-Ichi Fujikawa, Masashi Ohmae Biomacromolecules . 2007,第6期

机译：杂交糖胺聚糖的酶促共聚：多糖分子分子杂交的新策略
3. Enzymatic precision polymerization for synthesis of glycosaminoglycans and their derivatives [J] . Kobayashi S, Ohmae M, Fujikawa S, Macromolecular symposia . 2005,第0期

机译：酶促精密聚合反应合成糖胺聚糖及其衍生物
4. Enzymatic Polymerization: In Vitro Synthesis of Glycosaminoglycans and Their Derivatives [C] . Shiro Kobayashi, Shun-ichi Fujikawa, Ryosuke Itoh American Chemical Society Materials Symposium . 2005

机译：酶促聚合：体外合成糖胺聚糖及其衍生物
5. ENZYMATIC AND POLYPEPTIDE CHARACTERIZATION OF MORPHOLOGICALLY DEFINED REGIONS OF THE GUINEA PIG ACROSOME (SPERMATOZOA, HYALURONIDASE). [D] . WINER, MARTIN ABRAHAM. 1986

机译：几内亚猪精子（精子，透明质酸酶）的形态学定义区域的酶和多肽表征。
6. Mass spectrometric evidence for the enzymatic mechanism of the depolymerization of heparin-like glycosaminoglycans by heparinase II [O] . Andrew J. Rhomberg, Zachary Shriver, Klaus Biemann, 1998

机译：肝素酶II分解肝素样糖胺聚糖的酶促机理的质谱证据
7. Branched Poly(lactide) Synthesized by Enzymatic Polymerization: Effects of Molecular Branches and Stereochemistry on Enzymatic Degradation and Alkaline Hydrolysis [O] . -1

机译：由酶聚合合成的支化聚（丙交酯）：分子分支和立体化学对酶促降解和碱性水解的影响

A hyaluronidase supercatalyst for the enzymatic polymerization to synthesize glycosaminoglycans

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