• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Chemistry: A European journal >Molecule-responsive block copolymer micelles
【24h】

Molecule-responsive block copolymer micelles

机译：分子反应性嵌段共聚物胶束

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Ring-opening metathesis polymerization was used to generate an ABC triblock copolymer, containing complementary diamidopyridine (DAP) and thymine (THY) outer blocks, which assembles into spherical aggregates held together by DAP-THY noncovalent interactions. Addition of THY-containing small guest molecules results in complete opening and deaggregation of the block copolymer micelle. This molecular recognition and macroscopic response shows high selectivity to the guest structure, and tolerates only a small amount of conformational mobility in the THY guest. On the other hand, addition of a small DAP-containing guest does not break the aggregates, but instead, results in new micelles which show a different selectivity profile from the parent morphology. We have examined the effect of a number of structural features in the block copolymers, on both the extent and selectivity of their macroscopic response to guests (that is, opening of the micelle). This study has resulted in a set of structural guidelines, which help in the design of effective molecule-responsive micelles for applications in selective drug delivery, sensing, and surface patterning.
机译：开环易位聚合反应用于生成ABC三嵌段共聚物，其中包含互补的二氨基吡啶（DAP）和胸腺嘧啶（THY）外部嵌段，它们通过DAP-THY非共价相互作用组装成球形聚集体。含THY的小客体分子的加入导致嵌段共聚物胶束的完全打开和解聚。这种分子识别和宏观响应显示出对客体结构的高选择性，并且仅耐受THY客体中的少量构象迁移。另一方面，添加少量的含DAP的客体并不会破坏聚集体，而是会产生新的胶束，该胶束显示出与母体形态不同的选择性。我们已经研究了嵌段共聚物中许多结构特征对它们对客体的宏观反应（即，胶束的开口）的程度和选择性的影响。这项研究得出了一系列结构指导，可帮助设计有效的分子响应胶束，用于选择性药物递送，传感和表面构图。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号