High-Throughput Synthesis and Analysis of Acylated Cyanohydrins

Anders Hamberg; Stina Lundgren; Erica Wingstrand

首页> 外文期刊>Chemistry: A European journal >High-Throughput Synthesis and Analysis of Acylated Cyanohydrins

【24h】

High-Throughput Synthesis and Analysis of Acylated Cyanohydrins

机译：酰化氰醇的高通量合成与分析

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The yields and optical purities of products obtained from chiral Lewis acid/Lewis base-catalysed additions of alpha-ketonitriles to prochiral aldehydes could be accurately determined by an enzymatic method.The amount of remaining alde hyde was determined after its reduction to an alcohol,whilst the two product enantiomers were analysed after subsequent hydrolysis first by the(S)-selective Candida antarctica lipase B and then by the unselective pig liver esterase.The method could be used for analysis of products obtained from a number of aromat ic aldehydes and aliphatic ketonitriles.Microreactor technology was successfully combined with high-throughput analysis for efficient catalyst optimization.

机译：酶法可准确测定手性路易斯酸/路易斯碱催化的α-酮腈加到手性醛中的产物的收率和光学纯度。测定醛还原成醇后的残留醛量。水解后先用（S）-选择性南极假丝酵母脂肪酶B，然后用非选择性猪肝酯酶分析这两种产物对映体。该方法可用于分析由多种芳香醛和脂肪族乙腈制得的产物微反应器技术已成功地与高通量分析相结合，从而有效地优化了催化剂。

著录项

来源
《Chemistry: A European journal》 |2007年第15期|共8页
作者
Anders Hamberg; Stina Lundgren; Erica Wingstrand;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类化学;
关键词
asymmetric synthesis; cyanohydrins; enantioselectivity; enzymes; high-throughput screen ing; microreactors;

机译：不对称合成氰醇对映选择性酶高通量筛选微反应器;

相似文献

外文文献
中文文献
专利

1. High-Throughput Synthesis and Analysis of Acylated Cyanohydrins [J] . Anders Hamberg, Stina Lundgren, Erica Wingstrand Chemistry: A European journal . 2007,第15期

机译：酰化氰醇的高通量合成与分析
2. Synthesis of the beta(3)-Adrenergic Receptor Agonist Solabegron and Analogous N-(2-Ethylamino)-beta-amino Alcohols from O-Acylated Cyanohydrins - Expanding the Scope of Minor Enantiomer Recycling [J] . Hertzberg Robin, Santiago Guillermo Monreal, Moberg Christina The Journal of Organic Chemistry . 2015,第5期

机译：由O-酰化氰醇合成β（3）-肾上腺素能受体激动剂Solabegron和类似的N-（2-乙基氨基）-β-氨基醇-扩大了较小对映体回收的范围
3. Synthesis of the beta(3)-Adrenergic Receptor Agonist Solabegron and Analogous N-(2-Ethylamino)-beta-amino Alcohols from O-Acylated Cyanohydrins - Expanding the Scope of Minor Enantiomer Recycling [J] . Hertzberg Robin, Santiago Guillermo Monreal, Moberg Christina The Journal of Organic Chemistry . 2015,第5期

机译：由O-酰化氰醇合成β（3）-肾上腺素能受体激动剂Solabegron和类似的N-（2-乙基氨基）-β-氨基醇-扩大了较小对映体回收的范围
4. Spontaneous absolute asymmetric synthesis and self-replication in the Strecker-cyanohydrin synthesis in combination with conglomerate formation and asymmetric amplification [C] . Shohei Aiba, Naoya Takamatsu, Yuj i Tokunaga 日本化学会春季年会講演予稿集 . 2018

机译：与砾岩形成和不对称扩增组合的STRecker-氰基醇合成中自发绝对不对称合成及自复制
5. New avenues and applications for parallel library synthesis: I. Application of multicomponent reactions for the efficient synthesis of small molecule macroarrays. II. Characterization of non-native N-acylated L-homoserine lactones as bacterial biofilm inhibitors [D] . Lin, Qi 2007

机译：平行文库合成的新途径和应用：I.多组分反应在小分子大分子阵列有效合成中的应用。二。非天然N-酰化L-高丝氨酸内酯作为细菌生物膜抑制剂的表征
6. TBD- or PS-TBD-Catalyzed One-Pot Synthesis of Cyanohydrin Carbonates and Cyanohydrin Acetates from Carbonyl Compounds [O] . Satoru Matsukawa, Junya Kimura, Miki Yoshioka 2016

机译：TBD或PS-TBD催化从羰基化合物一锅法合成氰醇碳酸盐和氰醇乙酸盐
7. TBD- or PS-TBD-Catalyzed One-Pot Synthesis of Cyanohydrin Carbonates and Cyanohydrin Acetates from Carbonyl Compounds [O] . Satoru Matsukawa, Junya Kimura, Miki Yoshioka 2016

机译：TBD-或ps-TBD催化的羰基化合物一锅法合成氰醇碳酸酯和氰醇乙酸酯

High-Throughput Synthesis and Analysis of Acylated Cyanohydrins

摘要

著录项

相似文献

相关主题

期刊订阅