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首页> 外文期刊>Chemistry: A European journal >To be dinuclear or not: Z-DNA induction by nickel complexes
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To be dinuclear or not: Z-DNA induction by nickel complexes

机译：是否为双核：镍配合物诱导Z-DNA

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The left-handed Z-DNA has been identified as a gene regulating element. Therefore the generation of Z-DNA through metal complexes might be an innovative way for the regulation of gene expression. Use of the new dinuclear complex N,N,N',N'-tetrakis-[2(3,5-dimethylpyrazol-1-yl)ethyl]-1,3- propylenediamine-bis(nickel(II) dinitrate) (2) reversibly induced Z-DNA formation. However, when a 1:1 ratio of metal/dinucleating ligand was used as a control, the midpoint of the B- to Z-DNA transition was at the same nickel concentration as in case of the dinuclear complex. The novel mononuclear analogue, N-methyl-N,N-bis-[2(3,5-dimethylpyrazol-1-yl)ethyl]amine- nickel (II)-dinitrate (3) was inducing the Z-DNA at a similar ratio versus nucleotides as free nickel(II) itself. For the first time, proton and nickel binding constants for the bis-[2-(pyrazol-1-yl)ethyl]amine ligand system are reported and discussed. Both nickel complexes 2 and 3 were structurally characterized by single crystal analysis. Furthermore, the synthesis of the two new ligands, N,N,N',N'-tetrakis-[2-(3,5-dimethylpyrazol -1-yl)ethyl]-1,2-propylenediamine (4) and N-methyl-N,N-bis-[2(3,5-dimethylpyrazol-1-yl)ethyl]amine (5) is described. The two major synthetic pathways leading to polypyrazoyl amines in general are critically discussed with respect to yield, reproducibility and handling of the intermediates.
机译：左手Z-DNA已被鉴定为基因调节元件。因此，通过金属络合物生成Z-DNA可能是调节基因表达的创新方法。使用新的双核络合物N，N，N'，N'-四-[2（3,5-二甲基吡唑-1-基）乙基] -1,3-丙二胺-双（镍（二）镍）（2 ）可逆地诱导Z-DNA的形成。但是，当使用金属/异核配体的1：1比例作为对照时，B-Z-DNA过渡的中点与双核络合物的镍浓度相同。新型单核类似物N-甲基-N，N-双-[2（3,5-二甲基吡唑-1-基）乙基]胺-镍（II）-精制物（3）在相似的条件下诱导Z-DNA游离镍（II）本身与核苷酸的比率。首次报道和讨论了双-[2-（吡唑-1-基）乙基]胺配体系统的质子和镍结合常数。镍配合物2和3均通过单晶分析进行结构表征。此外，还合成了两个新的配体N，N，N'，N'-四-[2-（3,5-二甲基吡唑-1-基）乙基] -1,2-丙二胺（4）和N-描述了甲基-N，N-双-[2（3，5-二甲基吡唑-1-基）乙基]胺（5）。通常就中间体的产率，可再现性和操作性，对导致聚吡唑酰基胺的两个主要合成途径进行了严格的讨论。

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