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首页> 外文期刊>Chemistry: A European journal >Single-triggered AB(6) self-immolative dendritic amplifiers
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Single-triggered AB(6) self-immolative dendritic amplifiers

机译：单触发AB（6）自消树枝状放大器

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摘要

Self-immolative dendrimers are a unique class of molecules that are able to disassemble upon undergoing a specific triggering reaction through domino-like fragmentations. We have designed and synthesized a novel AB(6) self-immolative dendritic adaptor that amplifies a single cleavage event into the release of six reporter units. The disassembly mechanism is based on a specifically triggered cleavage event followed by elimination of a cyclic urea derivative and six consecutive quinone methide eliminations. The system was disassembled under both organic and aqueous conditions by either chemical or enzymatic triggering. Various reporter molecules and triggering groups were introduced onto the dendritic adaptor to obtaining sensor molecules with enhanced properties for diagnostics and imaging.
机译：自消散的树枝状大分子是一类独特的分子，能够通过类似多米诺骨牌的片段发生特定的触发反应而分解。我们已经设计并合成了一种新型的AB（6）自消灭性树突状衔接子，该衔接子将单个切割事件放大为六个报告单元的释放。拆卸机制基于特定触发的裂解事件，然后消除环状脲衍生物和连续六个六次醌甲基化物消除。通过化学或酶促引发在有机和水性条件下都可将系统拆解。将各种报告分子和触发基团引入树突状衔接子，以获得具有增强特性的传感器分子，用于诊断和成像。

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