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首页> 外文期刊>Technical physics letters: Letters to the Russian journal of applied physics >A Membrane-Separator Interface for Mass-Spectrometric Analysis of Blood Plasma
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A Membrane-Separator Interface for Mass-Spectrometric Analysis of Blood Plasma

机译：膜分离器接口，用于血浆的质谱分析

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摘要

We demonstrate the possibility of rapid mass-spectrometric determination of the content of anes- thetic agents in blood plasma with the aid of a membrane-separator interface. The interface employs a hydro- phobic selective membrane that is capable of separating various anesthetic drugs (including inhalation anes- thetic sevofluran, noninhalation anesthetic thiopental, hypnotic propofol, and opioid analgesic fentanyl) from the blood plasma and introducing samples into a mass spectrometer. Analysis of the blood plasma was not accompanied by the memory effect and did not lead to membrane degradation. Results of clinical inves- tigation of the concentration of anesthetics in the blood plasma of patients are presented.
机译：我们证明了借助膜分离器界面快速质谱测定血浆中麻醉剂含量的可能性。该界面采用疏水性选择性膜，该膜能够从血浆中分离出各种麻醉药（包括吸入麻醉药七氟醚，非吸入麻醉药硫喷妥钠，催眠丙泊酚和阿片类镇痛药芬太尼），并将样品引入质谱仪中。血浆分析不伴有记忆效应，也不会导致膜降解。给出了患者血浆中麻醉剂浓度的临床研究结果。

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