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首页> 外文期刊>Taiwanese journal of obstetrics and gynecology >Total hCG Versus Free P-hCG Combined with Alpha-fetoprotein for Down Syndrome Screening in Taiwan
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Total hCG Versus Free P-hCG Combined with Alpha-fetoprotein for Down Syndrome Screening in Taiwan

机译：总hCG与游离P-hCG结合甲胎蛋白对台湾唐氏综合症的筛查

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Objective: The purpose of this study was to compare the effectiveness between total human chorionic gonadotropin (hCG) and free P-hCG in two-marker Down syndrome screening programs during the second trimester in aTaiwanese population. Materials and Methods: From a multicenter collaborative study, we investigated the second-trimester maternal serum levels of total hCC from 67 data, free P-hCG from 72 and alpha-fetoprotein (AFP) from 96 obtained from Taiwanese pregnant women carrying fetuses with Down syndrome. Results: High total hCG and free P-hCG, as well as low AFP levels, were found with median values of 2.06, 2.49 and 0.77 multiples of the median (MoM),' respectively. At a 5% false-positive rate, total hCG and free beta-hCG could detect 31% and 43% of Down syndrome pregnancies, respectively, whilst AFP alone could detect only 15% of affected cases. When combined with maternal age-specific risk, total hCG could achieve a 52% detection rate, free p-hCG a 54% and AFP a 39%. Combined total hCG and AFP achieved a detection rate of 55%, and combined free P-hCG and AFP achieved a rate of 60%. Conclusion: The measurement of free P-hCG is more beneficial than total hCG in serum screening for Down syndrome during the second trimester of pregnancy.
机译：目的：本研究的目的是比较台湾人群中晚期三个标记物唐氏综合症筛查计划中总绒毛膜促性腺激素（hCG）和游离P-hCG的有效性。资料和方法：通过一项多中心合作研究，我们从67位台湾孕妇中收集了含唐氏胎儿的台湾孕妇，调查了67个数据的孕中期孕妇总hCC水平，72个游离P-hCG和96个α-甲胎蛋白（AFP）。综合症。结果：发现总hCG和游离P-hCG较高，AFP水平较低，分别为中值（MoM）的2.06、2.49和0.77倍。以5％的假阳性率，总hCG和游离β-hCG分别可以检测出唐氏综合症孕妇的31％和43％，而仅AFP可以检测到15％的患病病例。当结合孕妇的年龄特定风险时，总hCG检出率可达52％，游离p-hCG检出率为54％，AFP为39％。总hCG和AFP的结合检出率为55％，游离P-hCG和AFP的结合检出率为60％。结论：在妊娠中期妊娠唐氏综合症的血清筛查中，游离P-hCG的测定比总hCG更有利。

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