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首页> 外文期刊>Chemistry: A European journal >New Trends in the Chemistry of Iron(III) Citrate Complexes:Correlations between X-ray Structures and Solution Species Probed by Electrospray Mass Spectrometry and Kinetics of Iron Uptake from Citrate by Iron Chelators
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New Trends in the Chemistry of Iron(III) Citrate Complexes:Correlations between X-ray Structures and Solution Species Probed by Electrospray Mass Spectrometry and Kinetics of Iron Uptake from Citrate by Iron Chelators

机译：柠檬酸铁（III）配合物化学的新趋势：电喷雾质谱法检测X射线结构与溶液物种之间的相关性以及铁螯合剂从柠檬酸中吸收铁的动力学

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摘要

Despite the crucial role of "iron(III) citrate systems" in the iron metabolism of living organisms (bacteria as well as plants or mammals),the coordination chemistry of ferric citrate remains poorly defined.Variations in the experimental conditions used for the preparation of so-called ferric citrates (iron salt,Fe:cit molar ratio,base,pH,temperature,solvent) lead to several different species,which are in equilibrium in solution.To date,six different anionic complexes have been structurally characterized in the solid state,by ourselves or others.In the work described herein,we have established the experimental conditions leading to each of them.Five were obtained from aqueous solution.With the exception of a nonanuclear species (of which fragments have been detected), all were identified in aqueous solution on the basis of electrospray ionization mass spectrometry.In addition,the spectra revealed a new trinuclear species,which could not be crystallized.Kinetic studies of iron uptake from citrate species by iron chelators confirmed the results indicated by the ESI-MS studies.These studies also allowed the relative molar fraction of mononu-clear versus polynuclear complexes to be determined,which depends on the Fe :cit molar ratio.
机译：尽管“柠檬酸铁（III）系统”在活生物体（细菌以及植物或哺乳动物）的铁代谢中起着至关重要的作用，但柠檬酸铁的配位化学仍然很难确定。所谓的柠檬酸铁（铁盐，铁：柠檬酸的摩尔比，碱，pH，温度，溶剂）导致几种不同的物质，它们在溶液中处于平衡状态。迄今为止，在固体中已对六种不同的阴离子络合物进行了结构表征在本文所述的工作中，我们已经建立了导致每个条件的实验条件。五个是从水溶液中获得的。除了非核物种（已检测出碎片）之外，所有在电喷雾电离质谱的基础上鉴定了水溶液。此外，该光谱还揭示了一种新的三核物质，它无法结晶。铁吸收动力学铁螯合剂对柠檬酸盐种类的影响证实了ESI-MS研究表明的结果。这些研究还可以确定单核与多核配合物的相对摩尔分数，这取决于Fe：cit摩尔比。

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