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首页> 外文期刊>Talanta: The International Journal of Pure and Applied Analytical Chemistry >A simple method for the study of salbutamol pharmacokinetics by ion chromatography with direct conductivity detection
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A simple method for the study of salbutamol pharmacokinetics by ion chromatography with direct conductivity detection

机译：直接电导检测的离子色谱法研究沙丁胺醇药代动力学的简单方法

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摘要

A simple method for the study of the pharmacokinetics of salbutamol using ion chromatography with direct conductivity detection without chemical suppression is presented in this paper.Baseline separation of salbutamol from plasma components was achieved by using diluted HNO_3(2mmoll~(-1))as mobile phase with acetonitrile(6%,v/v)as modifier.Atenolol was utilized as internal standard.Under the optimal conditions,the linear regression coefficients of the calibration curves are 0.996 within the concentration range of 1000-3 ng ml~(-1)salbutamol.The detection limit(signal-to-noise ratio = 3)was 1 ngml~(-1)salbutamol.The noncompartmental pharmacokinetic parameters for salbutamol following administration of 8 mg salbutamol to 18 subjects were tested.The results coincided most satisfactorily with the results obtained by using reversed-phase high performance liquid chromatography(HPLC)with fluorescence detection.
机译：本文提出了一种简单的方法来研究沙丁胺醇的药代动力学，采用离子色谱法进行直接电导检测而无化学抑制，采用稀释的HNO_3（2mmoll〜（-1））作为流动相实现了沙丁胺醇与血浆成分的基线分离。乙腈（6％，v / v）为改性剂，以阿替洛尔为内标。在最佳条件下，浓度范围为1000-3 ng ml〜（-1）时，校正曲线的线性回归系数为0.996沙丁胺醇的检出限（信噪比= 3）为1 ngml〜（-1）沙丁胺醇。对18例受试者给予沙丁胺醇8毫克的非房室药代动力学参数进行了测试，结果最令人满意。反相高效液相色谱（HPLC）荧光检测获得的结果。

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