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首页> 外文期刊>Pathology >Utility of RhoC and ZAG protein expression as biomarkers for prediction of PSA failure following radical prostatectomy for high grade prostate cancer
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Utility of RhoC and ZAG protein expression as biomarkers for prediction of PSA failure following radical prostatectomy for high grade prostate cancer

机译：RhoC和ZAG蛋白表达作为生物标志物用于预测前列腺癌根治性前列腺切除术后PSA失败的生物标志物

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Aims: To assess the prognostic utility of semi-quantiative expression of RhoC protein in whole prostates from patients who had radical prostatectomies for high grade prostate cancer (PCa). Methods: Subjects who had surgery <55 months previously with primary Gleason pattern 4 PCa were identified from practice records, archival tissues were retrieved for review and RhoC immunohistochemistry, and ZAG expression was also assessed as a control. Results: Eighty-nine subjects were included in the study; 57 had a rising prostate specific antigen (PSA) post-operatively ('cases') and 32 did not ('controls'). By univariate analysis, expression of both RhoC and ZAG proteins was greater in controls than cases, but this was significant only for ZAG. By multivariate analysis, Gleason variables (patterns and score), extraprostatic extension and decreased RhoC staining all contributed to predicting PSA failure ( p<0.05). ZAG expression was inversely correlated with Gleason pattern and hence was not independently predictive in our multivariate model. Conclusions: Increased RhoC expression predicted a good outcome after radical prostatectomy. ZAG staining also correlated with a favourable outcome but was not independently predictive due to its relationship with Gleason pattern.
机译：目的：评估半定量前列腺癌根治术（PCa）患者在整个前列腺中RhoC蛋白半定量表达的预后效用。方法：从实践记录中鉴定出手术时间少于55个月且原发性Gleason模式4 PCa的受试者，检索档案组织进行回顾和RhoC免疫组织化学，并将ZAG表达也作为对照。结果：八十九名受试者被纳入研究。术后有57例前列腺特异性抗原（PSA）升高（“病例”），而32例则没有（“对照”）。通过单变量分析，对照组中RhoC和ZAG蛋白的表达均高于病例，但这仅对ZAG有意义。通过多变量分析，格里森变量（模式和评分），前列腺外延伸和RhoC染色减少均有助于预测PSA失败（p <0.05）。 ZAG表达与格里森模式成反比，因此在我们的多元模型中不是独立预测的。结论：RhoC表达增加预示了前列腺癌根治术后的良好结局。 ZAG染色也与良好的结果相关，但由于其与格里森模式的关系而不能独立预测。

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