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首页> 外文期刊>Pathology case reviews. >Pulmonary Sarcoidosis: Necrotizing Granulomas on Explant, With Recurrence on Surveillance Biopsies
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Pulmonary Sarcoidosis: Necrotizing Granulomas on Explant, With Recurrence on Surveillance Biopsies

机译：肺结节病：外植体坏死性肉​​芽肿，活检组织复发

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Pulmonary involvement is common in sarcoidosis. Patients may be asymptomatic but frequently develop lung symptoms if there is extensive parenchymal or airway involvement by granulomatous inflammation or if there is progression to fibrotic lung disease. Histolog-ically, the diagnosis of sarcoid is one of exclusion, and the presence of nonnecrotizing granulomas on biopsy is supportive of the diagnosis. Occasionally, sarcoid granulomas have central necrosis; although this pattern is associated with vascular involvement, it is unclear if necrotizing sarcoid granulomatosis is a distinct clinicopathologic entity. We report a case of pulmonary sarcoidosis that progressed to end-stage lung disease; at transplant, some of the granulomas showed central necrosis, although there was no vascular involvement and otherwise the findings were typical of pulmonary sarcoid. Surveillance biopsy at 1 year showed recurrence with nonnecrotizing granulomas.
机译：肺结节在结节病中很常见。如果肉芽肿性炎症累及实质或气道，或者进展为纤维化性肺病，则患者可能无症状，但经常出现肺部症状。从组织学上讲，肉瘤的诊断是排除之一，活检中非坏死性肉芽肿的存在有助于诊断。有时，结节性肉芽肿具有中央坏死。尽管这种模式与血管受累有关，但尚不清楚坏死性结节性肉芽肿病是否是独特的临床病理学实体。我们报告了一例肺结节病，该病已发展为终末期肺部疾病;移植时，一些肉芽肿显示中心坏死，尽管没有血管受累，否则发现是肺结节的典型表现。 1年的活检显示非坏死性肉芽肿复发。

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