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首页> 外文期刊>Pathology International >Fluorescence in situ hybridization analysis with a tissue microarray: 'FISH and chips' analysis of pathology archives.
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Fluorescence in situ hybridization analysis with a tissue microarray: 'FISH and chips' analysis of pathology archives.

机译：组织微阵列的荧光原位杂交分析：病理档案的“ FISH和芯片”分析。

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Practicing pathologists expect major somatic genetic changes in cancers, because the morphological deviations in the cancers they diagnose are so great that the somatic genetic changes to direct these phenotypes of tumors are supposed to be correspondingly tremendous. Several lines of evidence, especially lines generated by high-throughput genomic sequencing and genome-wide analyses of cancer DNAs are verifying their preoccupations. This article reviews a comprehensive morphological approach to pathology archives that consists of fluorescence in situ hybridization with bacterial artificial chromosome (BAC) probes and screening with tissue microarrays to detect structural changes in chromosomes (copy number alterations and rearrangements) in specimens of human solid tumors. The potential of this approach in the attempt to provide individually tailored medical practice, especially in terms of cancer therapy, is discussed.
机译：实际的病理学家期望癌症中的重大体细胞遗传学改变，因为他们诊断出的癌症的形态学差异是如此之大，以至于指导这些肿瘤表型的体细胞遗传学改变据认为是巨大的。几条证据，特别是高通量基因组测序和癌症DNA的全基因组分析所产生的证据正在证实它们的重要性。本文回顾了一种病理学档案学的综合形态学方法，该方法包括与细菌人工染色体（BAC）探针进行荧光原位杂交，并用组织微阵列进行筛选，以检测人类实体瘤标本中染色体的结构变化（拷贝数变化和重排）。讨论了这种方法在提供个性化医疗实践方面的潜力，尤其是在癌症治疗方面。

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