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首页> 外文期刊>Pathology Research and Practice >Morphological signs of cirrhosis regression. Experimental observations on carbon tetrachloride-induced liver cirrhosis of rats.
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Morphological signs of cirrhosis regression. Experimental observations on carbon tetrachloride-induced liver cirrhosis of rats.

机译：肝硬化的形态学指标消退。四氯化碳诱导的大鼠肝硬化的实验观察。

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摘要

Regression of hepatic cirrhosis is a controversial issue. Recently, a list of histopathological features, observed in human material, was suggested as a hallmark of cirrhosis in the process of regression. An investigation for the presence of these morphologic features was performed at monthly intervals in rats with proved carbon tetrachloride (CCl4)-induced cirrhosis over a period of 9 months following discontinuation of treatment, using sequential liver biopsies. Within the first 4 months, features of the "hepatic repair complex" were identified, together with the enlargement of the hepatic nodules and thinning of the fibrous septa. Subsequent to the 4 months, the histological picture, composed of large and inconspicuous nodules and delimited by thin and frequently incomplete fibrous septa "incomplete septal cirrhosis", appeared to be stabilized. These fibrous septa, when injected with India ink from the portal trunk, presented blood vessels that were seen to drain directly into the sinusoids. These findings suggested that when the cause of cirrhosis is removed, the liver may adapt itself to a new and permanent structure, probably compatible with normal or near-normal function, which may render hepatic cirrhosis clinically, although not morphologically, reversible.
机译：肝硬化的回归是一个有争议的问题。最近，有人在人体材料中观察到的组织病理学特征列表被认为是肝硬化在回归过程中的标志。使用连续的肝活检法，在停药后的9个月内，对已证明四氯化碳（CCl4）诱导的肝硬化的大鼠，每月进行一次有关这些形态特征存在的调查。在最初的4个月内，发现了“肝修复复合物”的特征，以及肝结节扩大和纤维间隔变薄。在这四个月之后，由大而不起眼的结节组成的组织学图像似乎已稳定，由稀薄且经常不完整的纤维间隔“不完全间隔性肝硬化”界定。这些纤维隔膜在从门脉干注入印度墨水时会呈现出直接排入正弦曲线的血管。这些发现表明，除去肝硬化的病因后，肝脏可能会适应新的永久性结构，可能与正常或接近正常的功能相适应，这可能使肝硬化在临床上可逆，尽管在形态上并非如此。

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