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首页> 外文期刊>Pathology oncology research: POR >Stimuli-induced organ-specific injury enhancement of organotropic metastasis in a spatiotemporal regulation.
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Stimuli-induced organ-specific injury enhancement of organotropic metastasis in a spatiotemporal regulation.

机译：刺激引起的器官特异性器官损伤在时空调节中增强。

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The relationship between inflammation and tumorigenesis has been established. Recently, inflammation is also reported to be a drive force for cancer metastasis. Further evidences show that various stimuli directly induced-injury in a specific organ can also promote metastasis in this organ, which include epidemiological reports, clinical series and experimental studies. Each type of cancer has preferential sites for metastasis, which is also due to inflammatory factors that are released by primary cancer to act on these sites and indirectly induce injuries on them. Host factors such as stress,fever can also influence distant metastasis in a specific site through stimulation of immune and inflammatory effects. The five aspects support an idea that specific-organ injury directly induced by various stimuli or indirectly induced by primary tumor or host factors activation of proinflammatory modulators can promote metastasis in this organ through a spatiotemporal regulation, which has important implications for personalized prediction, prevention and management of cancer metastasis.
机译：炎症和肿瘤发生之间的关系已经建立。最近，据报道炎症也是癌症转移的驱动力。进一步的证据表明，特定器官中各种直接引起的损伤也可以促进该器官的转移，包括流行病学报告，临床系列研究和实验研究。每种类型的癌症都有转移的优先位点，这也是由于原发性癌症释放的炎症因子作用于这些位点并间接引起伤害。诸如发烧，发烧等宿主因素也可通过刺激免疫和炎性作用来影响特定部位的远处转移。这五个方面支持这样一种观点，即各种刺激直接诱导或原发肿瘤或宿主因子激活促炎调节剂间接诱导的特定器官损伤可通过时空调节促进该器官的转移，这对于个性化的预测，预防和控制具有重要意义。癌症转移的管理。

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