Stereotactic Radiotherapy in the Retreatment of Recurrent Cervical Cancers, Assessment of Toxicity, and Treatment Response: Initial Results and Literature Review

Pontoriero Antonio; Iati Giuseppe; Aiello Dario; Pergolizzi Stefano

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Stereotactic Radiotherapy in the Retreatment of Recurrent Cervical Cancers, Assessment of Toxicity, and Treatment Response: Initial Results and Literature Review

机译：立体定向放射疗法在复发性宫颈癌的再治疗，毒性评估和治疗反应方面的初步结果和文献综述

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Aim: To evaluate the role of stereotactic body radiation therapy in the retreatment of locally recurrent cervical cancers. Brachytherapy is the main choice to treat gynecologic cancers. Methods: Patients with recurrent cervical cancer, previously submitted to radiotherapy, were treated with stereotactic body radiation therapy using a CyberKnife system (Accuray Incorporated, Sunnyvale, California) with a fiducial tracking system. Results: From August 2011 to October 2014, 5 patients have been treated. Median age was 81 years (range, 70-84 years). Two patients were diagnosed with adenocarcinoma endometrioid and 3 with squamous cell carcinoma. Toxicity was scored according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria. After a median follow-up of 12 months (range, 8-34 months), no severe (>grade 3) acute/late genitourinary or low gastrointestinal toxicity was observed. Conclusion: Our preliminary results of stereotactic body radiation therapy "simulating'' high dose rate for recurrent cervical cancers confirm a minimal toxicity and an optimal outcome. The stereotactic body radiation therapy is an alternative to high dose rate brachytherapy for gynecologic tumors.

机译：目的：评估立体定向放射疗法在局部复发宫颈癌的再治疗中的作用。近距离放射疗法是治疗妇科癌症的主要选择。方法：先前采用放射疗法的复发性子宫颈癌患者使用带有基准跟踪系统的CyberCnife系统（Accuray Incorporated，Sunnyvale，California）进行立体定向放射治疗。结果：2011年8月至2014年10月，共收治5例患者。中位年龄为81岁（范围为70-84岁）。 2例被诊断为子宫内膜样腺癌，3例被诊断为鳞状细胞癌。根据放射治疗肿瘤学小组/欧洲癌症研究和治疗组织标准对毒性进行评分。在中位随访12个月（8-34个月）后，未观察到严重的（> 3级）急性/晚期泌尿生殖道毒性或低胃肠道毒性。结论：我们的立体定向放射疗法“模拟”高剂量率用于复发性宫颈癌的初步结果证实了最小的毒性和最佳的结局，立体定向放射疗法是高剂量率妇科肿瘤近距离放射疗法的替代方法。

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《Technology in cancer research & treatment.》 |2016年第6期|共7页
作者
Pontoriero Antonio; Iati Giuseppe; Aiello Dario; Pergolizzi Stefano;
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正文语种 eng
中图分类肿瘤学;
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gynecologic cancer; recurrent cervical cancer; CyberKnife; stereotactic body radiation therapy;

机译：妇科癌症;复发性宫颈癌;网络刀;立体定向放射疗法;

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1. Stereotactic Radiotherapy in the Retreatment of Recurrent Cervical Cancers, Assessment of Toxicity, and Treatment Response: Initial Results and Literature Review [J] . Pontoriero Antonio, Iati Giuseppe, Aiello Dario, Technology in cancer research & treatment. . 2016,第6期

机译：立体定向放射疗法在复发性宫颈癌的再治疗，毒性评估和治疗反应方面的初步结果和文献综述
2. Combined chemotherapy plus endostar with sequential stereotactic radiotherapy as salvage treatment for recurrent esophageal cancer with severe dyspnea: A case report and review of the literature [J] . XuM., HuangH., XiongY., Oncology letters . 2014,第1期

机译：联合化疗+ endostar联合序贯立体定向放射治疗挽救复发性食管癌伴重度呼吸困难：一例报告并文献复习
3. Examining tumor control and toxicity after stereotactic body radiotherapy in locally recurrent previously irradiated head and neck cancers: Implications of treatment duration and tumor volume [J] . VargoJ.A., HeronD.E., FerrisR.L., Head and neck: Journal for the sciences and specialities of the head and neck . 2014,第9期

机译：立体定向放疗后局部复发的先前放射过的头颈癌的肿瘤控制和毒性检查：治疗持续时间和肿瘤体积的含义
4. Radiomics versus physician assessment for the early prediction of local cancer recurrence after stereotactic radiotherapy for lung cancer [C] . Sarah A. Mattonen, Carol Johnson, David A. Palma, Conference on medical imaging . 2016

机译：放射学与医师评估对肺癌进行立体定向放射治疗后局部癌症复发的早期预测
5. Analysis of Single Nucleotide Polymorphisms (SNPs) and Dose-volume Parameters on Predicting for Rectal Toxicity, Erectile Dysfunction, and Urinary Morbidity Following Treatment for Prostate Cancer Using Radiotherapy. [D] . Taneja, Sameer. 2014

机译：分析单核苷酸多态性（SNP）和剂量参数对使用放射疗法治疗前列腺癌后的直肠毒性，勃起功能障碍和尿毒症的预测。
6. Combined chemotherapy plus endostar with sequential stereotactic radiotherapy as salvage treatment for recurrent esophageal cancer with severe dyspnea: A case report and review of the literature [O] . MINGFANG XU, HUAN HUANG, YANLI XIONG, -1

机译：联合化疗+ endostar联合序贯立体定向放射治疗挽救复发性食管癌伴重度呼吸困难：一例报告并文献复习
7. Long-term outcome and toxicity of hypofractionated stereotactic body radiotherapy as a boost treatment for head and neck cancer: the importance of boost volume assessment [O] . Dong Lee, Yeon Kim, Jae Cheon, 2012

机译：超分割立体定向放射疗法作为头颈癌的增强疗法的长期结果和毒性：增强容量评估的重要性

Stereotactic Radiotherapy in the Retreatment of Recurrent Cervical Cancers, Assessment of Toxicity, and Treatment Response: Initial Results and Literature Review

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