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首页> 外文期刊>Technology in cancer research & treatment. >Benefits of six degrees of freedom for optically driven patient set-up correction in SBRT.
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Benefits of six degrees of freedom for optically driven patient set-up correction in SBRT.

机译：六个自由度的优势可用于SBRT中的光驱患者结构校正。

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摘要

To quantify the advantages of a 6 degrees of freedom (dof) versus the conventional 3- or 4-dof correction modality for stereotactic body radiation therapy (SBRT) treatments. Eighty-five patients were fitted with 5-7 infra-red passive markers for optical localization. Data, acquired during the treatment, were analyzed retrospectively to simulate and evaluate the best approach for correcting patient misalignments. After the implementation of each correction, the new position of the target (tumor's center of mass) was estimated by means of a dedicated stereotactic algorithm. The Euclidean distance between the corrected and the planned location of target point was calculated and compared to the initial mismatching. Initial and after correction median+/-quartile displacements affecting external control points were 3.74+/-2.55 mm (initial), 2.45+/-0.91 mm (3-dof), 2.37+/-0.95 mm (4-dof), and 2.03+/-1.47 mm (6-dof). The benefit of a six-parameter adjustment was particularly evident when evaluating the results relative to the target position before and after the re-alignment. In this context, the Euclidean distance between the planned and the current target point turned to 0.82+/-1.12 mm (median+/-quartile values) after the roto-translation versus the initial displacement of 2.98+/-2.32 mm. No statistical improvements were found after 3- and 4-dof correction (2.73+/-1.22 mm and 2.60+/-1.31 mm, respectively). Angular errors were 0.09+/-0.93 degrees (mean+/-std). Pitch rotation in abdomen site showed the most relevant deviation, being -0.46+/-1.27 degrees with a peak value of 5.46 degrees . Translational misalignments were -0.68+/-2.60 mm (mean+/-std) with the maximum value of 12 mm along the cranio-caudal direction. We conclude that positioning system platforms featuring 6-dof are preferred for high precision radiation therapy. Data are in line with previous results relative to other sites and represent a relevant record in the framework of SBRT.
机译：为了量化6自由度（dof）相对于立体定向身体放射疗法（SBRT）治疗的传统3或4dof矫正方式的优势。 85位患者装有5-7个红外被动标记以进行光学定位。回顾性分析治疗期间获得的数据，以模拟和评估纠正患者错位的最佳方法。实施每次校正后，将通过专用立体定位算法估算目标的新位置（肿瘤的质心）。计算校正点和目标点计划位置之间的欧几里得距离，并将其与初始失配进行比较。初始和校正后，影响外部控制点的中值+/-四分位位移为3.74 +/- 2.55 mm（初始），2.45 +/- 0.91 mm（3-dof），2.37 +/- 0.95 mm（4-dof）和2.03 +/- 1.47毫米（6-dof）在评估重新对齐前后相对于目标位置的结果时，六参数调整的好处特别明显。在这种情况下，旋转平移后的计划目标点与当前目标点之间的欧式距离变为0.82 +/- 1.12 mm（中值+/-四分位数），而初始位移为2.98 +/- 2.32 mm。在进行3-dof和4dof校正后（分别为2.73 +/- 1.22 mm和2.60 +/- 1.31 mm），没有发现统计学上的改善。角误差为0.09 +/- 0.93度（平均+/-标准差）。腹部部位的俯仰旋转显示最相关的偏差，为-0.46 +/- 1.27度，峰值为5.46度。平移未对准为-0.68 +/- 2.60 mm（平均+/- std），沿颅尾方向最大为12 mm。我们得出结论，具有6-dof的定位系统平台是高精度放射治疗的首选。数据与先前相对于其他站点的结果一致，并且代表了SBRT框架中的相关记录。

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