The formation of Heterodimers by Vancomycin Group Antibiotics

Staroske Thomas; OftBrien Dominic P.

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The formation of Heterodimers by Vancomycin Group Antibiotics

机译：万古霉素类抗生素形成异二聚体

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The formation of heterodimers in mixtures of glycopeptide antibiotics has been detected by electrospray ionization mass spectrometry (ESI-MS), and dimerization constants have been determined. By using NMR spectroscopy, it has been shown that these heterodimers indeed exist in aqueous solution. The dimerization constants obtained by NMR spectroscopy are in good agreement with those determined by ESI-MS. Structural information on the heterodimer interface of some of the heterodimers is obtained by using two-dimensional NMR techniques and reveals that these heterodimers are similar in structure to the homodimers.

机译：已通过电喷雾电离质谱（ESI-MS）检测到糖肽抗生素混合物中异二聚体的形成，并确定了二聚化常数。通过使用NMR光谱，已经表明这些异二聚体确实存在于水溶液中。通过NMR光谱获得的二聚常数与通过ESI-MS测定的二聚常数非常吻合。通过使用二维NMR技术获得了一些异二聚体的异二聚体界面的结构信息，并揭示了这些异二聚体的结构与同二聚体相似。

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《Chemistry: A European journal》 |2000年第3期|共6页
作者
Staroske Thomas; OftBrien Dominic P.;
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正文语种 eng
中图分类化学;应用化学;
关键词
antibiotics; heterodimers; mass spectrometry; NMR spectroscopy; vancomycin;

机译：抗生素;异二聚体;质谱;NMR光谱;万古霉素;

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1. The formation of Heterodimers by Vancomycin Group Antibiotics [J] . Staroske Thomas, OftBrien Dominic P. Chemistry: A European journal . 2000,第3期

机译：万古霉素类抗生素形成异二聚体
2. In vitro evaluation of a fibrin gel antibiotic delivery system containing mesenchymal stem cells and vancomycin alginate beads for treating bone infections and facilitating bone formation [J] . HouT., XuJ., LiQ., Tissue engineering, Part A . 2008,第7期

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3. Synthesis and Conformational Properties of the M(4-6)(5-7) Bicyclic Tetrapeptide Common to the Vancomycin Antibiotics [J] . David A. Evans, Christopher J. Dinsmore, Andrew M. Ratz Journal of the American Chemical Society . 1997,第14期

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4. Risk Factors for Development of Antibiotic Resistance of Enterococcus Faecium to Vancomycin. A Subgroup Discovery Approach [C] . Andrej Fajfar, Manuel Campos, Francisco Palacios, Conference of the Spanish Association for Artificial Intelligence . 2018

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5. The Ecology of Antibiotic Resistance: Sources and Persistence of Vancomycin-Resistant Enterococci and Antibiotic Resistance Genes in Aquatic Environments [D] . Young, Suzanne M. 2017

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6. Inhibition of the Autolytic System by Vancomycin Causes Mimicry of Vancomycin-Intermediate Staphylococcus aureus-Type Resistance Cell Concentration Dependence of the MIC and Antibiotic Tolerance in Vancomycin-Susceptible S. aureus [O] . Krzysztof Sieradzki, Alexander Tomasz 2006

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The formation of Heterodimers by Vancomycin Group Antibiotics

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