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首页> 外文期刊>The American journal of otology >Octylcyanoacrylate: a new medical-grade adhesive for otologic surgery.
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Octylcyanoacrylate: a new medical-grade adhesive for otologic surgery.

机译：氰基丙烯酸辛酯：一种用于耳科手术的新型医疗级粘合剂。

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HYPOTHESIS: The adhesive octylcyanoacrylate is not associated with significant inner ear toxicity in a guinea pig model. BACKGROUND: Many cyanoacrylate adhesives have been investigated for use in otologic surgery, but variable ototoxicity has been reported. Octylcyanoacrylate is a medical-grade adhesive with many properties that make it ideal for use in the ear. It is free of contaminants; it forms a strong, flexible bond; and it inhibits the growth of gram-positive organisms in culture. This is the first study to assess the ototoxicity of this new adhesive. METHODS: Fourteen adult guinea pigs were used. Preoperative auditory brainstem responses (ABRs) were determined. Bilateral antrotomies were performed, and the ears were randomized to adhesive and control (saline) groups. In the adhesive ears. 0.5 or 0.1 mL of octylcyanoacrylate was instilled into the middle ear. Eight weeks later, postoperative ABRs were determined, the animals were killed, and the temporal bones were removed. Middle ear changes were noted, and the ossicular chain was assessed. Cochlear hair cell analyses were performed. Histologic assessment of the middle ear mucosa was performed. RESULTS: There was a higher incidence of conductive hearing loss in the adhesive group secondary to fixation of the ossicular chain, but there was no significant difference in bone conduction thresholds. The median postoperative bone conduction thresholds (dB peak sound pressure level) was 15.0 in the control group and 17.5 in the adhesive group, p = 0.89. There was also no significant difference in inner hair cell counts (0.4% vs. 0.5% median hair cell loss, p = 0.72) or outer hair cell counts (3.7% vs. 3.0% median hair cell loss, p = 0.23) for the adhesive and control groups, respectively. Histopathologic analysis of the middle ear mucosa demonstrated variable mild to moderate foreign body reaction with no evidence of mucosal ulceration or necrosis. CONCLUSIONS: A large amount of octylcyanoacrylate placed in the middle ear of the guinea pig did not cause any morphologic or functional evidence of inner ear toxicity. This new adhesive is a promising tool for otologic surgery.
机译：假设：在豚鼠模型中，氰基丙烯酸丙烯酸辛酯与明显的内耳毒性无关。背景：已经研究了许多氰基丙烯酸酯粘合剂用于耳科手术的方法，但据报道耳毒性可变。氰基丙烯酸辛酯是一种医学级粘合剂，具有许多特性，使其非常适合在耳朵中使用。不含污染物;它形成牢固，灵活的结合;它抑制了革兰氏阳性生物在培养中的生长。这是评估这种新粘合剂的耳毒性的第一项研究。方法：使用14只成年豚鼠。确定术前听觉脑干反应（ABR）。进行双侧解剖，将耳朵随机分为黏附组和对照组（盐水组）。在胶粘的耳朵里。将0.5或0.1 mL氰基丙烯酸辛酯滴入中耳。八周后，确定了术后ABR，杀死了动物，并取下了颞骨。记录中耳变化，并评估听骨链。进行耳蜗毛细胞分析。对中耳黏膜进行组织学评估。结果：听骨链固定继发的黏附剂组传导性听力损失的发生率较高，但骨传导阈值无显着差异。术后中位骨传导阈值中值（dB峰值声压水平）在对照组中为15.0，在粘合组中为17.5，p = 0.89。内毛细胞数（0.4％vs. 0.5％中性毛细胞损失，p = 0.72）或外毛细胞数（3.7％vs. 3.0％中性毛细胞损失，p = 0.23）也没有显着差异。粘附组和对照组。中耳黏膜的组织病理学分析表明轻度至中度异物反应不定，没有黏膜溃疡或坏死的迹象。结论：豚鼠中耳放置大量氰基丙烯酸丙烯酸辛酯不会引起内耳毒性的任何形态学或功能性证据。这种新的粘合剂是用于耳科手术的有前途的工具。

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