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首页> 外文期刊>The American journal of otology >Dose-related vestibular and cochlear effects of transtympanic gentamicin.
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Dose-related vestibular and cochlear effects of transtympanic gentamicin.

机译：鼓膜庆大霉素的剂量相关前庭和耳蜗作用。

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HYPOTHESIS: To test the relative dose-related cochlear and vestibular ototoxicity produced by transtympanically injected gentamicin in the Mongolian gerbil. BACKGROUND: Transtympanic gentamicin is gaining favor as a relatively noninvasive treatment for Meniere's disease (MD). Few basic science studies exist regarding the vestibular and cochlear toxicities and dosage and administration schedules, however. The absence of standardized procedures and use of different species as animal models may account for the variable outcomes and lack of agreement found in the literature. METHODS: Histologic evaluation was performed on inner ears from Mongolian gerbils to study vestibular and cochlear damage. Comparisons were made between animals receiving single (1x) and five (5x) daily injections of gentamicin/gelfoam slurry and similarly injected (saline/gelfoam) and noninjected controls. RESULTS: Two weeks after injection, qualitative and quantitative changes were seen in posterior cristae hair cells in the 1x and 5x gentamicin injected groups. Statistically significant decreases in hair cells were seen when 5x injected ears were compared with 1x injected ears and when 1x injected ears were compared with control ears. When damage was observed in the posterior crista sensory cells, damage was also seen in cochlear hair cells. CONCLUSIONS: Our results suggest that in the gerbil, gentamicin is ototoxic but not selectively vestibulotoxic. In general, increasing the number of transtympanic injections increases the damage to sensory hair cells in both the posterior crista and the cochlea. A variation in interanimal susceptibility to ototoxic effects exists, but the amount of damage is consistent in both cochlear and vestibular hair cells from the same animal.
机译：假设：为了测试通过鼓室注射庆大霉素在蒙古沙鼠中产生的相对剂量相关的耳蜗和前庭耳毒性。背景：鼓膜庆大霉素作为美尼尔氏病（MD）的相对非侵入性治疗方法正在受到欢迎。然而，很少有关于前庭和耳蜗毒性以及剂量和给药方案的基础科学研究。缺乏标准化的程序以及使用不同物种作为动物模型可能导致文献中发现了可变的结果和缺乏共识。方法：对蒙古沙鼠的内耳进行组织学评估，以研究前庭和耳蜗的损伤。在接受单次（1x）和五次（5x）每日注射庆大霉素/明胶泡沫浆以及类似注射液（盐水/明胶泡沫液）和未注射对照的动物之间进行比较。结果：注射后两周，庆大霉素注射组分别注射1x和5x后cr毛细胞发生质和量的变化。当将5次注射的耳朵与1次注射的耳朵进行比较，以及将1次注射的耳朵与对照组的耳朵进行比较时，毛细胞的统计显着减少。当在后cr感觉细胞中观察到损伤时，在耳蜗毛细胞中也观察到损伤。结论：我们的结果表明，在沙鼠中，庆大霉素具有耳毒性，但没有选择性前庭毒性。通常，增加鼓室注射的次数会增加对后cr和耳蜗中感官毛细胞的损害。动物间对耳毒性作用的敏感性存在差异，但是在同一动物的耳蜗和前庭毛细胞中，损伤的程度是一致的。

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