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首页> 外文期刊>The American journal of otology >Influence of CO2 laser application to the guinea-pig cochlea on compound action potentials.
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Influence of CO2 laser application to the guinea-pig cochlea on compound action potentials.

机译：CO2激光照射豚鼠耳蜗对复合动作电位的影响。

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HYPOTHESIS: Experiments in guinea pigs were performed to clarify which, if any, of the CO2 lasers in different modes (continuous wave [cw] and superpulse) can damage the inner ear on application of the laser parameters required for stapedotomy and to determine their application safety. METHODS: The laser effect connected with perforating the basal convolution of the guinea-pig cochlea (cochleostomy) was examined. Acoustic evoked potentials (compound action potentials [CAPs]) yielded information on inner-ear function. RESULTS: In cw mode, even single applications of an approximately four times higher power density (60,000 W/cm2) than necessary for stapedotomy at a pulse duration of 50 msec (energies up to 1 J) and 20-fold applications of effective parameters for a footplate perforation (power density 16,000 W/cm2; energy 0.2 J) did not cause CAP changes. Experimental studies with the CO2 superpulse laser used (peak pulse powers: ca. 300 W) have demonstrated that irreversible CAP alterations already occur in the effective laser range in > 40% of the animals. CONCLUSIONS: Because damage is expected only at much higher energies (> 2 J) than those used clinically, the CO2 laser in cw mode has a high application safety for laser stapedotomy. The application of the CO2 laser in superpulse mode with peak pulse powers of approximately 300 W in stapedotomy appears to be more unreliable and dangerous for the inner ear.
机译：假设：在豚鼠中进行了实验，以弄清楚在使用骨切开术所需的激光参数时，不同模式（连续波[cw]和超脉冲）的CO2激光（如果有）会损坏内耳，并确定其应用安全。方法：研究了与豚鼠耳蜗基底回旋穿孔相关的激光效果（耳蜗切开术）。声诱发电位（复合动作电位[CAPs]）产生了内耳功能的信息。结果：在连续模式下，即使是单次应用，其功率密度（60,000 W / cm2）大约比stapedotomy所需的功率密度高出四倍，脉冲持续时间为50毫秒（能量高达1 J），有效参数的应用是20倍踏板穿孔（功率密度16,000 W / cm2;能量0.2 J）没有引起CAP改变。使用二氧化碳超脉冲激光器（峰值脉冲功率：约300 W）进行的实验研究表明，有效激光范围内> 40％的动物已经发生了不可逆的CAP改变。结论：由于预期仅在比临床上使用的能量高得多的能量下（> 2 J）才会造成损害，因此连续模式的CO2激光在激光骨切开术中具有很高的应用安全性。在骨切开术中以峰值脉冲功率约为300 W的超脉冲模式使用CO2激光对内耳来说似乎更加不可靠且危险。

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