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首页> 外文期刊>The American Journal of Surgery >Normocalcemic hyperparathyroidism: Preoperatively a disease, postoperatively cured?
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Normocalcemic hyperparathyroidism: Preoperatively a disease, postoperatively cured?

机译：正常钙化甲状旁腺功能亢进症：术前有病，术后能治愈吗？

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Background: Up to 44% of primary hyperparathyroidism patients have elevated parathyroid hormone (ePTH) with normal calcium postparathyroidectomy (PTx). The question is whether the surgical approach affects the incidence of this phenomenon. Methods: Patients with hyperparathyroidism and presumed single-gland disease on preoperative imaging who underwent PTx between 1994 and 2008 were identified and contacted for long-term follow-up. PTx was either a focused approach (minimally invasive approach [MIP]) or a bilateral neck exploration (BNE). Results: In total, 171 patients had PTH measured postoperatively (95 MIP and 76 BNE); 30 of 171 (17%) had ePTH with normal calcium (MIP 21 [22%] and BNE 9 [12%], P =.08). This occurred within 2 years in 48% and 67% and after 2 years in 52% and 33%, MIP vs BNE, respectively. Four patients recurred, 2 MIP and 2 BNE. Conclusions: There is a trend toward a higher incidence of ePTH in patients having undergone an MIP. The etiology of ePTH is multifactorial but may represent an early recurrence.
机译：背景：多达44％的原发性甲状旁腺功能亢进症患者甲状旁腺钙化术后正常（PTx）甲状旁腺激素（ePTH）升高。问题是手术方法是否会影响这种现象的发生。方法：确定1994年至2008年间接受PTx治疗的术前影像学检查中甲状旁腺功能亢进和单发性腺病患者，并进行长期随访。 PTx既可以是集中治疗（微创治疗[MIP]），也可以是双侧颈部探查（BNE）。结果：共有171例患者术后进行了PTH测量（95 MIP和76 BNE）。 171名患者中有30名（17％）的ePTH与正常钙（MIP 21 [22％]和BNE 9 [12％]，P = .08）。 MIP vs BNE分别在2年内以48％和67％发生，在2年后以52％和33％发生。复发4例，分别为2例MIP和2例BNE。结论：发生MIP的患者存在ePTH发生率较高的趋势。 ePTH的病因是多因素的，但可能代表早期复发。

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