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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Urban leptospirosis in Africa: A cross-sectional survey of Leptospira infection in rodents in the Kibera urban settlement, Nairobi, Kenya
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Urban leptospirosis in Africa: A cross-sectional survey of Leptospira infection in rodents in the Kibera urban settlement, Nairobi, Kenya

机译：非洲城市钩端螺旋体病：肯尼亚内罗毕基贝拉城市居民区啮齿类动物钩端螺旋体感染的横断面调查

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摘要

Leptospirosis is a widespread but under-reported cause of morbidity and mortality. Global re-emergence of leptospirosis has been associated with the growth of informal urban settlements in which rodents are thought to be important reservoir hosts. Understanding the multi-host epidemiology of leptospirosis is essential to control and prevent disease. A cross-sectional survey of rodents in the Kibera settlement in Nairobi, Kenya was conducted in September-October 2008 to demonstrate the presence of pathogenic leptospires. A real-time quantitative polymerase chain reaction showed that 41 (18.3%) of 224 rodents carried pathogenic leptospires in their kidneys, and sequence data identified Leptospira interrogans and L. kirschneri in this population. Rodents of the genus Mus (37 of 185) were significantly more likely to be positive than those of the genus Rattus (4 of 39; odds ratio = 15.03). Questionnaire data showed frequent contact between humans and rodents in Kibera. This study emphasizes the need to quantify the public health impacts of this neglected disease at this and other urban sites in Africa.
机译：钩端螺旋体病是发病率和死亡率的普遍但未报告的原因。钩端螺旋体病的全球再次出现与非正式城市住区的增长有关，在这些城市中，啮齿动物被认为是重要的宿主。了解钩端螺旋体病的多宿主流行病学对于控制和预防疾病至关重要。 2008年9月至10月，对肯尼亚内罗毕的基贝拉定居点的啮齿动物进行了横断面调查，以证明存在致病性钩端螺旋体。实时定量聚合酶链反应显示，在224只啮齿动物中，有41只（18.3％）在其肾脏中携带致病性钩端螺旋体，而序列数据确定了该种群中的问号钩端螺旋体和克氏杆菌。 Mus属的啮齿动物（185个中的37个）比Rattus属的啮齿动物（39个中的4个;优势比= 15.03）更有可能是阳性的。问卷调查数据显示，基贝拉人与啮齿动物之间频繁接触。这项研究强调需要量化这种被忽视疾病在非洲这个城市和其他城市地区对公共健康的影响。

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