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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Differential expression of glycerol-3-phosphate dehydrogenase isoforms in flight muscles of the Chagas disease vector Triatoma infestans (Hemiptera, Reduviidae)
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Differential expression of glycerol-3-phosphate dehydrogenase isoforms in flight muscles of the Chagas disease vector Triatoma infestans (Hemiptera, Reduviidae)

机译：Chagas病媒Triatoma infestans（Hemiptera，Reduviidae）飞行肌肉中的3-磷酸甘油脱氢酶亚型的差异表达

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摘要

Flight muscles of Triatoma infestans have two glycerol-3-phosphate dehydrogenase (GPDH) isoforms: GPDH-1 is involved in flight metabolism and GPDH-2 provides lipid precursors. Total GPDH activity was greater in the natural population and almost only due to GPDH-1. Different expression and activity observed between GPDH isoforms in the natural population and the first laboratory generation was not detected in the second laboratory generation. This pattern may be caused by gradual adaptation to laboratory nutritional conditions. During development, the expression of GPDH-2 increased with a longer time of intake, which would imply an increment in lipid biosynthesis. The GPDH-1 transcript predominated with respect to that of GPDH-2 in the lower nutritional condition, suggesting the necessity of insects to fly during this nutritional status. The transcriptional pattern showed a delay at 22°C. The isoforms activities and transcript patterns in flight muscles suggest transcriptional adaptation to metabolic requirements originated by alternative splicing.
机译：Triatoma infestans的飞行肌肉有两种3-磷酸甘油脱氢酶（GPDH）亚型：GPDH-1参与飞行代谢，GPDH-2提供脂质前体。在自然种群中，总GPDH活性更高，几乎仅归因于GPDH-1。在第二代实验室中未检测到自然种群和第一代实验室中GPDH同工型之间观察到的不同表达和活性。这种模式可能是由于逐渐适应实验室的营养条件引起的。在发育过程中，GPDH-2的表达随着摄入时间的延长而增加，这意味着脂质生物合成的增加。在营养水平较低的情况下，相对于GPDH-2而言，GPDH-1转录本占优势，这表明昆虫在这种营养状态下需要飞翔。转录模式显示在22°C下有延迟。飞行肌肉中的同工型活动和转录本模式表明转录适应由其他剪接产生的代谢需求。

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