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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Artesunate/amodiaquine malaria treatment for Equatorial Guinea (Central Africa)
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Artesunate/amodiaquine malaria treatment for Equatorial Guinea (Central Africa)

机译：青蒿琥酯（中部非洲）的青蒿琥酯/阿地二喹疟疾治疗

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摘要

The objectives of this study were: 1) to evaluate the safety and efficacy of combination artesunate (AS)/amodiaquine (AQ) therapy, and 2) to determine the difference between recrudescence and resistance. An in vivoefficacy study was conducted in Equatorial Guinea. A total of 122 children 6-59 months of age from two regionalhospitals were randomized and subjected to a 28-day clinical and parasitological follow-up. A blood sample on Whatmanpaper was taken on Days 0, 7, 14, 21, and 28 or on any day in cases of treatment failure, with the parasite DNA then beingextracted for molecular analysis purposes. A total of 4 children were excluded, and 9 cases were lost to follow-up. Therewere 17 cases of late parasitological failure, 3 cases of late clinical failure, and 89 cases of adequate clinical and parasitological response. The parasitological failure rate was 18.3% (20 of 109) and the success rate 81.70% (95% confidence interval [72.5-87.9%]). After molecular correction, real treatment efficacy stood at 97.3%. Our study showed the good efficacy of combination AS/AQ therapy. This finding enabled this treatment to be recommended to Equatorial Guinea's National Malaria Control Program to change the official treatment policy as of March 2008.
机译：这项研究的目的是：1）评价青蒿琥酯（AS）/氨二喹（AQ）联合治疗的安全性和有效性，以及2）确定复发和耐药之间的差异。在赤道几内亚进行了体内功效研究。来自两个地区医院的总共122名6-59个月的儿童被随机分配并接受28天的临床和寄生虫学随访。在第0、7、14、21和28天或治疗失败的任何一天在Whatmanpaper上采集血样，然后提取寄生虫DNA以进行分子分析。总共排除了4名儿童，有9例失访。晚期寄生虫学失败17例，晚期临床失败3例，充分的临床和寄生虫学反应89例。寄生虫学失败率为18.3％（109人中有20人），成功率为81.70％（95％置信区间[72.5-87.9％]）。分子校正后，实际治疗效率为97.3％。我们的研究显示了联合AS / AQ治疗的良好疗效。这一发现使这种治疗方法可以推荐给赤道几内亚的国家疟疾控制计划，以更改自2008年3月起的官方治疗政策。

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