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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Rationale for the coadministration of albendazole and ivermectin to humans for malaria parasite transmission control
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Rationale for the coadministration of albendazole and ivermectin to humans for malaria parasite transmission control

机译：将阿苯达唑和伊维菌素共同给药于人以控制疟疾寄生虫传播的理由

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摘要

Recently there have been calls for the eradication of malaria and the elimination of soil-transmitted helminths (STHs). Malaria and STHs overlap in distribution, and STH infections are associated with increased risk for malaria. Indeed, there is evidence that suggests that STH infection may facilitate malaria transmission. Malaria and STH coinfection may exacerbate anemia, especially in pregnant women, leading to worsened child development and more adverse pregnancy outcomes than these diseases would cause on their own. Ivermectin mass drug administration (MDA) to humans for malaria parasite transmission suppression is being investigated as a potential malaria elimination tool. Adding albendazole to ivermectin MDAs would maximize effects against STHs. A proactive, integrated control platform that targets malaria and STHs would be extremely cost-effective and simultaneously reduce human suffering caused by multiple diseases. This paper outlines the benefits of adding albendazole to ivermectin MDAs for malaria parasite transmission suppression.
机译：最近，人们呼吁消灭疟疾和消除土壤传播的蠕虫（STH）。疟疾和STH分布重叠，STH感染与疟疾风险增加相关。确实，有证据表明STH感染可能促进疟疾传播。疟疾和STH合并感染可能会加剧贫血，尤其是在孕妇中，导致儿童发育恶化和比这些疾病单独导致的不良妊娠结局更多。伊维菌素对人类的疟疾寄生虫传播抑制的大规模药物管理（MDA）正在研究中作为一种潜在的消除疟疾的工具。在伊维菌素MDA中添加阿苯达唑将最大程度地提高对STH的作用。一个针对疟疾和STH的积极，综合的控制平台将具有极高的成本效益，并同时减少多种疾病引起的人类痛苦。本文概述了在艾维菌素MDA中添加阿苯达唑对抑制疟原虫传播的益处。

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