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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Correlation between Serum Levels of Anti-Endothelial Cell Autoantigen and Anti-Dengue Virus Nonstructural Protein 1 Antibodies in Dengue Patients
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Correlation between Serum Levels of Anti-Endothelial Cell Autoantigen and Anti-Dengue Virus Nonstructural Protein 1 Antibodies in Dengue Patients

机译：登革热患者血清抗内皮细胞自身抗原水平与抗登革热病毒非结构蛋白1抗体的相关性

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摘要

We have previously shown that anti dengue virus nonstructural protein 1 (anti-DENV NS1) antibodies cross-react with endothelial cells, and several autoantigens have been identified. This study shows that the antibody levels against these self-proteins are higher in sera from patients with dengue hemorrhagic fever (DHF) than those in control sera. Anti protein disulfide isomerase (PDI) and anti heat shock protein 60 (anti-HSP60) IgM levels correlated with both anti endothelial cells and anti-DENV NS1 IgM titers. A cross-reactive epitope on the NS1 amino acid residues 311-330 (P311-330) had been predicted. We further found that there were higher IgM and IgG levels against P311-330 in DHF patients' sera than those in the control sera. In addition, correlations were observed between anti-PDI with anti-P31 P311-330 IgM and IgG levels, respectively. Therefore, our results indicate that DENV NS1 P311-330 is a major epitope for cross-reactive antibodies to PDI on the endothelial cell surface, which may play an important role in DENV infection induced autoimmunity.
机译：先前我们已经表明，抗登革热病毒非结构蛋白1（anti-DENV NS1）抗体与内皮细胞发生交叉反应，并且已经鉴定出几种自身抗原。这项研究表明，登革出血热（DHF）患者的血清中针对这些自身蛋白的抗体水平高于对照血清。抗蛋白质二硫键异构酶（PDI）和抗热休克蛋白60（抗HSP60）IgM水平与抗内皮细胞和抗DENV NS1 IgM滴度相关。已经预测到NS1氨基酸残基311-330（P311-330）上具有交叉反应性表位。我们还发现，在DHF患者的血清中，针对P311-330的IgM和IgG水平高于对照血清。另外，分别在抗PDI与抗P31 P311-330 IgM和IgG水平之间观察到相关性。因此，我们的结果表明，DENV NS1 P311-330是内皮细胞表面针对PDI的交叉反应抗体的主要表位，这可能在DENV感染诱导的自身免疫中起重要作用。

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