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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Antioxidant status and acute malaria in children in Kampala, Uganda.
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Antioxidant status and acute malaria in children in Kampala, Uganda.

机译：乌干达坎帕拉儿童的抗氧化状况和急性疟疾。

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摘要

Although antioxidant status has been implicated in the pathogenesis of malaria, these factors need further characterization. A longitudinal study was conducted involving 273 children 1-10 years of age with acute, uncomplicated malaria in Kampala, Uganda. Plasma vitamin A, carotenoids, and vitamin E were measured at enrollment and on day 7. Malaria parasitemia was measured at enrollment, on day 3, and on day 7. Malaria parasitemia had completely cleared in 57.1% and 85.3% of children by day 3 and day 7, respectively. Plasma vitamin A, alpha-carotene, beta-carotene, lycopene, lutein/zeaxanthin, and vitamin E were depressed at enrollment and increased by day 7. Multivariate analyses showed that higher plasma lycopene concentrations at enrollment were associated with clearance of parasitemia between enrollment and day 3 (odds ratio = 1.46, 95% confidence interval = 1.07-2.06, per 0.10 micromol/L of lycopene). This study suggests that children with acute malaria have depressed plasma concentrations of antioxidants, and that higher plasma lycopene is associated with more rapid clearance of malaria parasitemia.
机译：尽管抗氧化剂的状态与疟疾的发病机理有关，但是这些因素还需要进一步表征。在乌干达的坎帕拉，进行了一项纵向研究，涉及273名1-10岁的急性，单纯性疟疾儿童。在入组时和第7天测量血浆维生素A，类胡萝卜素和维生素E。在入组时，第3天和第7天测量疟疾寄生虫病。到第3天，57.1％和85.3％的儿童疟疾寄生虫病已完全清除。和第7天。入组时血浆维生素A，α-胡萝卜素，β-胡萝卜素，番茄红素，叶黄素/玉米黄质和维生素E降低并在第7天增加。多因素分析显示，入组时血浆番茄红素浓度升高与入组与入组之间的寄生虫病清除率相关。第3天（每0.10 micromol / L番茄红素的赔率= 1.46、95％置信区间= 1.07-2.06）。这项研究表明，患有急性疟疾的儿童血浆抗氧化剂的浓度降低，而血浆番茄红素水平越高，疟疾寄生虫病的清除速度越快。

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