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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >PLASMODIUM FALCIPARUM MALARIA IN SPLENECTOMIZED PATIENTS: TWO CASE REPORTS IN FRENCH GUIANA AND A LITERATURE REVIEW.
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PLASMODIUM FALCIPARUM MALARIA IN SPLENECTOMIZED PATIENTS: TWO CASE REPORTS IN FRENCH GUIANA AND A LITERATURE REVIEW.

机译：全科患者恶性疟原虫疟疾：法属圭亚那的两例病例报告和文献复习。

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摘要

Some of the immunologic mechanisms involved in malaria physiopathology remain unclear. In animals, the spleen seems to play a key role in protecting the host against malaria. However, little is known about the effect of spleen dysfunction on human malaria. We report two severe cases of Plasmodium falciparum infection with unusual clinical and parasitologic features in two splenectomized men living in French Guiana. The peripheral blood of these cases showed hyperparasitemia, with a high proportion of mature parasites and leukocytes with malaria pigment. Despite appropriate treatment and adequate absorption, hyperparasitemia persisted. Parasite clearance was delayed and one patient died. Only the patient who died had the merozoite surface protein 1 allele B-K1 and the varD gene genotype, which is considered to be a probable parasite virulence factor. These uncommon cases differ from most of those described in the literature, illustrating the complexity of the mechanisms underlying the protective function of the spleen in human malaria.
机译：涉及疟疾生理病理学的某些免疫学机制仍不清楚。在动物中，脾脏似乎在保护宿主抵抗疟疾中起关键作用。然而，关于脾功能障碍对人类疟疾的影响知之甚少。我们报告了两个严重的恶性疟原虫感染病例，其中两名居住在法属圭亚那的脾脏切除男性中有异常的临床和寄生虫学特征。这些病例的外周血表现为高寄生虫血症，其中大部分是带有疟疾色素的成熟寄生虫和白细胞。尽管进行了适当的治疗和充分的吸收，高寄生虫血症仍持续存在。寄生虫清除被延迟，一名患者死亡。仅死亡的患者具有裂殖子表面蛋白1等位基因B-K1和varD基因基因型，这被认为是可能的寄生物致病因子。这些罕见的病例与文献中描述的大多数病例不同，说明了脾脏在人类疟疾中的保护功能所依据的机制十分复杂。

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