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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Immune responses against Plasmodium falciparum asexual blood-stage antigens and disease susceptibility in Gabonese and Cameroonian children.
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Immune responses against Plasmodium falciparum asexual blood-stage antigens and disease susceptibility in Gabonese and Cameroonian children.

机译：加蓬和喀麦隆儿童对恶性疟原虫无性血液阶段抗原的免疫反应和疾病易感性。

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摘要

The frequency and level of cellular and humoral responses to seven synthetic peptides from asexual blood stages of Plasmodium falciparum were measured in two cohorts of children living in areas highly endemic for malaria in Gabon and Cameroon. A prospective longitudinal study was conducted for one year in these sites to examine the relationship between specific in vitro immune responses and susceptibility to clinical malaria. Clinical protection was related to high proliferative responses (merozoite surface antigen-1 [MSA-1] and MSA-2 peptides) as well as to elevated antibody levels (schizont extract, MSA-2, and rhoptry-associated protein-1 [RAP-1] peptides) in the village of Dienga, Gabon. Higher response rates of interferon-gamma but lower response rates of tumor necrosis factor-alpha to four and six peptides, respectively, were observed in Dienga than in Pouma that were independent of the older age of the Gabonese children. Age accounted only for the higher prevalence rate in Dienga of the antibody responders to the peptide from Pf155/ring-infected erythrocyte surface antigen (RESA). Our results support the inclusion of epitopes from MSA-1, MSA-2, RAP-1, and Pf155/RESA antigens in a subunit vaccine against malaria, but show that a longitudinal clinical, parasitologic, and immunologic study conducted according to identical criteria in two separate areas may lead to contrasting observations, demonstrating the geographic limitation of the interpretation of such results.
机译：在加蓬和喀麦隆的两个疟疾高发地区儿童中，对恶性疟原虫无性血液中的七个合成肽的细胞和体液反应的频率和水平进行了测量。在这些部位进行了为期一年的前瞻性纵向研究，以检查特定的体外免疫应答与临床疟疾易感性之间的关系。临床保护与高增殖反应（裂殖子表面抗原-1 [MSA-1]和MSA-2肽）以及升高的抗体水平（裂殖体提取物，MSA-2和与rhoptry相关的蛋白-1 [RAP- 1]肽）在加蓬Dienga村。独立于加蓬儿童的年龄，在迪安加，观察到干扰素-γ的应答率较高，而肿瘤坏死因子-α对4和6个肽的应答率分别较低。年龄仅解释了来自Pf155 /环感染的红细胞表面抗原（RESA）的肽的抗体应答者在Dienga中较高的患病率。我们的研究结果支持将MSA-1，MSA-2，RAP-1和Pf155 / RESA抗原的抗原决定簇包含在针对疟疾的亚基疫苗中，但表明根据相同的标准进行的纵向临床，寄生虫学和免疫学研究两个独立的区域可能导致观察结果相反，这说明了此类结果解释的地理局限性。

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