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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Formation of Infectious Dengue Virus Antibody Immune Complex In Vivo in Marmosets (Callithrix jacchus) After Passive Transfer of Anti-Dengue Virus Monoclonal Antibodies and Infection with Dengue Virus
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Formation of Infectious Dengue Virus Antibody Immune Complex In Vivo in Marmosets (Callithrix jacchus) After Passive Transfer of Anti-Dengue Virus Monoclonal Antibodies and Infection with Dengue Virus

机译：被动转移抗登革热病毒单克隆抗体并感染登革热病毒后，Mar猴（Callithrix jacchus）体内感染性登革热病毒抗体免疫复合物的形成。

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摘要

Infection with a dengue virus (DENY) serotype induces cross-reactive, weakly neutralizing antibodies to different dengue serotypes. It has been postulated that cross-reactive antibodies form a virus-antibody immune complex and enhance DENV infection of Fc gamma receptor (Fc gamma R)-bearing cells. We determined whether infectious DENV-antibody immune complex is formed in vivo in marmosets after passive transfer of DENV-specific monoclonal antibody (mAb) and DENV inoculation and whether infectious DENY-antibody immune complex is detectable using Fc gamma R-expressing cells. Marmosets showed that DENV-antibody immune complex was exclusively infectious to Fc gamma R-expressing cells on days 2, 4, and 7 after passive transfer of each of the mAbs (mAb 4G2 and mAb 6B6C) and DENV inoculation. Although DENV-antibody immune complex was detected, contribution of the passively transferred antibody to overall viremia levels was limited in this study. The results indicate that DENV cross-reactive antibodies form DEN V-antibody immune complex in vivo, which is infectious to Fc gamma R-bearing cells but not Fc gamma R-negative cells.
机译：登革热病毒（DENY）血清型感染可诱导针对不同登革热血清型的交叉反应，弱中和抗体。据推测，交叉反应抗体形成病毒-抗体免疫复合物并增强携带Fcγ受体（FcγR）的细胞的DENV感染。我们确定了在被动转移DENV特异性单克隆抗体（mAb）和DENV接种后，mar猴体内是否在体内形成了传染性DENV抗体免疫复合物，以及是否可以使用表达FcγR的细胞检测到传染性DENY抗体免疫复合物。 mos猴显示，在被动转移每种mAb（mAb 4G2和mAb 6B6C）和DENV接种后的第2、4和7天，DENV抗体免疫复合物仅感染FcγR表达细胞。尽管检测到了DENV-抗体免疫复合物，但在这项研究中被动转移抗体对总体病毒血症水平的贡献是有限的。结果表明，DENV交叉反应性抗体在体内形成DEN V抗体免疫复合物，可感染带有FcγR的细胞，但不感染FcγR阴性的细胞。

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