...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA.
【24h】

Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA.

机译：抑制Bothrops asper蛇毒诱发的局部出血和皮肤坏死：肽模拟物金属蛋白酶抑制剂batimastat和螯合剂CaNa2EDTA早期就地给药的有效性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The effectiveness of the chelating agent CaNa2EDTA and the peptidomimetic matrix metalloproteinase inhibitor batimastat (BB-94) to inhibit local tissue damage induced by Bothrops asper snake venom was studied in mice. Both compounds totally inhibited proteolytic, hemorrhagic, and dermonecrotic effects, and partially reduced edema-forming activity, when incubated with venom prior to injection. Much lower concentrations of batimastat than of CaNa2EDTA were required to inhibit these effects. In addition, batimastat, but not CaNa2EDTA, partially reduced myotoxic activity of the venom. When the inhibitors were administered at various time intervals after envenomation at the same site of venom injection, both compounds were effective in neutralizing local hemorrhage and dermonecrosis if administered rapidly after venom. Inhibition was not as effective as the time lapse between venom and inhibitor injections increased. Owing to the relevance of metalloproteinases in the pathogenesis of local tissue damage induced by B. asper and other pit viper venoms, it is suggested that administration of peptidomimetic metalloproteinase inhibitors or CaNa2EDTA at the site of venom injection may represent a useful alternative to complement antivenoms in the neutralization of venom-induced local tissue damage.
机译：在小鼠中研究了螯合剂CaNa2EDTA和拟肽基质金属蛋白酶抑制剂batimastat（BB-94）抑制由Bothrops asper蛇毒引起的局部组织损伤的有效性。当在注射前与毒液一起孵育时，两种化合物都完全抑制蛋白水解，出血和皮肤坏死作用，并部分降低水肿形成活性。抑制这些作用所需的巴马司他浓度要比CaNa2EDTA低得多。此外，巴马司他而不是CaNa2EDTA可以部分降低毒液的肌毒性活性。当在毒液注入后的同一时间在毒液注入后的不同时间间隔使用抑制剂时，如果在毒液后迅速施用，两种化合物均有效中和局部出血和皮肤坏死。抑制效果不如毒液和抑制剂注射之间的时间间隔增加。由于金属蛋白酶与枯草芽孢杆菌和其他凹坑蛇毒所致的局部组织损伤的发病机制有关，因此建议在毒液注射部位施用拟肽金属蛋白酶抑制剂或CaNa2EDTA可能是补充补充抗蛇毒血清的有用方法。中和毒液引起的局部组织损伤。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号