...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Randomized intervention study comparing several regimens for the treatment of moderate anemia among refugee children in Kigoma Region, Tanzania.
【24h】

Randomized intervention study comparing several regimens for the treatment of moderate anemia among refugee children in Kigoma Region, Tanzania.

机译：随机干预研究比较了坦桑尼亚基戈马地区难民儿童中度贫血的几种治疗方案。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Anemia-specific mortality was markedly elevated among refugee children < 5 years of age in Tanzania. In a randomized, double-blind study, 215 anemic children were initially treated for malaria and helminth infection and then received 12 weeks of thrice-weekly oral iron and folic acid. Group I received placebo and chloroquine treatment for symptomatic malaria infection (i.e., no presumptive anti-malarial treatment given). Group II received placebo and monthly presumptive treatment with sulfamethoxazole-pyrimethamine (SP). Group III also received monthly SP and thrice-weekly vitamins A and C (VAC). Mean hemoglobin concentration increased from 6.6 to 10.2 g/dL, with no significant differences among groups. Group II had lower mean serum transferrin receptor levels (TfR) than group I [P = 0.023]. A greater proportion of participants in group III had normal iron stores (TfR < 8.5 microg/ mL) than in group II [P = 0.012]. Initial helminth and malaria treatment, followed by thrice-weekly iron and folic acid supplements resulted in increased hemoglobin levels. Monthly SP and thrice-weekly VAC contributed to improve iron stores. Monthly SP may have a role in situations where asymptomatic disease is prevalent or where access to care is limited. Because administration of VAC also hastened recovery of iron stores over administration of monthly SP alone, health care personnel could add VAC to the treatment for moderate anemia if maximum recovery of iron stores is desired.
机译：在坦桑尼亚，小于5岁的难民儿童中因贫血引起的死亡率明显升高。在一项随机，双盲研究中，最初对215名贫血儿童进行了疟疾和蠕虫感染的治疗，然后每周12次每周三次口服铁和叶酸。第一组接受有症状疟疾感染的安慰剂和氯喹治疗（即未给予推定的抗疟疾治疗）。第二组接受安慰剂，并每月用磺胺甲恶唑-乙胺嘧啶（SP）进行推定治疗。第三组还每月接受SP和每周三次维生素A和C（VAC）。平均血红蛋白浓度从6.6增加到10.2 g / dL，各组之间无显着差异。第二组的平均血清转铁蛋白受体水平（TfR）低于第一组[P = 0.023]。与第二组相比，第三组的参与者具有正常的铁存储（TfR <8.5 microg / mL）[P = 0.012]。最初的蠕虫和疟疾治疗，然后每周三次补充铁和叶酸，导致血红蛋白水平升高。每月SP和每周三次VAC有助于改善铁存储。在无症状疾病盛行或获得护理有限的情况下，每月SP可能会起作用。由于VAC的管理还比单独每月SP的管理还加快了铁存储的恢复，因此，如果希望最大程度地恢复铁存储，医护人员可以将VAC添加到中度贫血的治疗中。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号